Compositions containing ibuprofen

Details Compositions containing ibuprofen Compositions containing ibuprofen

1987-09-17

1989-06-06

Dixon, Jr., William R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, 424490, 424492, 424494, 424497, A61K 914

Patent

active

048370312

ABSTRACT:
A granular composition containing 2-(4-isobutylphenyl)propionic acid (ibuprofen) as an active anti-inflammatory pharmaceutical ingredient as a major component, together with carboxymethylcellulose, a lubricant and water as minor components, is disclosed. Particles of ibuprofen and carboxymethylcellulose are both fluidized and coated with an aqueous disperson of a starch binder. After being dried to a moisture level of about 1-5% and blended with a lubricant and additional carboxymethylcellulose, the resulting granules can be directly molded into a pharmaceutically acceptable tablet having high hardness, short disintegration time and fast dissolution rate.

REFERENCES:
patent: 4036948 (1972-07-01), Kitamori et al.
patent: 4439453 (1984-03-01), Vogel
patent: 4555399 (1985-11-01), Hsiao
patent: 4562024 (1985-12-01), Rogerson
patent: 4609675 (1986-09-01), Franz
patent: 4661521 (1987-04-01), Salpekar et al.

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