Compositions containing HMG Co-A reductase inhibitors and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S419000, C514S423000, C514S460000, C514S548000, C514S724000

Reexamination Certificate

active

06890941

ABSTRACT:
The present invention provides pharmaceutical compositions, methods, combinations, and kits for treating a disorder related to elevated serum cholesterol concentration, for example, hypercholesterolemia, atherosclerosis, elevated LDL plasma levels, low HDL plasma levels, hypertriglyceridemia, hyperlipidemia, hypertension, cholesterol gallstones, and lipid storage diseases. The compositions, methods, combinations, and kits of the present invention are pharmaceutical compositions comprising atherapeutically effective amount of a lipid regulating agent, such as a HMG-CoA reductase inhibitor, and compound that inhibits cholesterol synthesis at a point between the formation of acetate and mevalonate. A typical pharmaceutical composition of the invention contains and effective amount of atorvastatin and an effective amount of policosanol.

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patent: 5856316 (1999-01-01), Laguna Granja et al.
patent: 20030232796 (2003-12-01), Cooper et al.
Medline Abstract, Moroyama et al. Current Drug Targets. Cardiovascular & haematological disorders (2004 Mar) 4 (1) 35 52.*
Medline Abstract, Illingworth, Cardiology (1989), 76 Suppl 1 83-94; discussion 94-100.

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