Compositions containing esters of unsaturated fatty acids

Details Compositions containing esters of unsaturated fatty acids Compositions containing esters of unsaturated fatty acids

1994-01-06

1997-02-18

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514169, 552544, A61K 3156, C07J 900

Patent

active

056042167

ABSTRACT:
Pharmaceutical and nutritional compositions are disclosed containing, in association with a suitable diluent or carrier, at least 10% by weight of a cholesterol fatty acid ester where the fatty acid is gamma-linolenic acid, dihomo-gamma-linolenic acid, adrenic acid, the 22:5 n-6 acid, stearidonic acid, the 20:4 n-3 acid, eicosapentaenoic acid, docosahexaenoic acid, the 22:5 n-3 acid or columbinic acid. Novel cholesterol columbinic acid esters are described.

REFERENCES:
Rovesti; "Impieghi Cosmetologici Degli Arachidonati Di Colesterile E Di Ascorbile"; Riv. Ital. Essemze-Profumi, Piante Offic., Aromi-Saponi, Cosmet-Aerosol.; vol. 50, No. 8, 1968, pp. 432-434.
Abdulla et al.; "Differential Resorption Rates of Subcutaneous Implants of [.sup.3 H]Cholesterol, Varios [.sup.3 H]Cholesterol esters and [.sup.3 H]Cholesterol-[1-.sup.14 C]Linolenate; Journal of Atherosclerosis Research"; vol. 9, No. 1, 1969; pp. 81-85.
Sklart et al.; "Induced Circular Dichroism of Incorporated Fluorescent Cholesteryl Esters and Polar Lipids as a Probe of Human Serum Low Density Lipoprotein Structure and Melting"; J. Biol. Chem.; vol. 256, No. 9, 1981; pp. 4286-4292.
Rossner et al.; "Fat Emulsions with Added Free Cholesterol or Fatty Acid Cholesteryl Esters"; Nutr. Metab.; vol. 21, No. 6, 1977; pp. 349-357.
Pownall et al.; "Effect of Saturated and Polyunsaturated Fat Diets on the Composition and Structure of Human Low Density Lipoproteins"; Atherosclerosis; vol. 36, No. 3, 1980; pp. 299-314.
Subbaiah et al.; "Incorporation of Dietary N-3 Fatty Acids Into Molecular Species of Phosphatidyl Choline and Cholesteryl Ester in Normal Human Plasma .sup.1-3 "; Am. J. Clin. Nutr.; vol. 58, 1993; pp. 360-368.
X. Fang et al. "High Performance liquid chromatography . . . " Jour. of Liquid Chromatography, 14(3), 1991, pp. 589-598.
E. Hoving et al. "Separation of cholesterol esters . . . " Jour. of Chromatography, 565 (1991), pp. 103-110.
J. H. Shand et al. "The esterification of cholesterol in the yolk . . . " Lipids, 28(7), 1993, pp. 621-625.
Intl Journal of Clinical Pharmacology Therapy & Toxicology, 1986, 24(12), pp. 668-670.
European Drug Directory, Ed. 2, Paris, SEMP Editions, 1992, p. 1249.
Kagawa et al, Chemical Abstracts, vol. 102, No. 23, abstract #203048u, 1985, p. 523.
Glick et al, Chemical Abstracts, vol. 107, No. 3, abstract #21426m, 1987, p. 438.

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