Compositions containing dialkyl (C.sub.1 -C.sub.6)-ketone peroxi

Details Compositions containing dialkyl (C.sub.1 -C.sub.6)-ketone peroxi Compositions containing dialkyl (C.sub.1 -C.sub.6)-ketone peroxi

1997-02-18

1999-10-19

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Embalming or undertaking compositions

27 221, 27 222, A01N 100

Patent

active

059684976

DESCRIPTION:

BRIEF SUMMARY
TECHNICAL FIELD OF THE INVENTION

The present invention fits in the technical field of the preservation of organic animal or human tissues. More specifically, the invention provides compositions useful for temporary or indefinite preservation of dead tissues and human and animal corpses, against natural rotting processes and contamination with fungi.


PRIOR ART OF THE INVENTION

Preservation of animal and human corpses as well as of organs and tissues removed from said corpses has a long tradition in history initially due to cultural reasons and, approximately since the Renaissance also for the purpose of anatomical studies.
Nowadays, the preservation of human corpses is still done for cultural reasons but also for pathological and anatomical studies and the transport of corpses from one place to another. Likewise, the preservation of animal corpses is still being used, in public and private education, in addition to the above mentioned purposes.
Current preservation technologies are essentially based on embalming techniques and by immersion for which different agents are used. Such agents are alcohol as a fixing agent and preservative, tannic acid as a means to prevent the growth of fungi, mercury bichloride to inhibit decay and to facilitate mummification, arsenic, glycerol, paraffin, combinations of acetone and silicone as well as formaldehyde or formol discovered by the chemist Wilhelm V, Hofmann in 1868. Due to its low cost and excellent preserving properties, formol is still the agent most widely used as the preservative of animal and human corpses and tissues and its cost is still low.
However, due to its relative toxicity and its possible harmful and even cancerigenic effects, the use of formaldehyde is presently being questioned in scientific circles and by health administrations and there are studies and projects that consider the prohibition of the use of formol as a preservative. Aside from this, formaldehyde also has the well known disadvantages such as being an agent that irritates the mucous membranes and respiratory tract and that also has a typical smell that is usually perceived as very unpleasant.
On the other hand, by means of conventional preservation techniques and the use of current preservatives, total protection of the tissues against natural processes of decay by microbiological agents, fungi is not achieved, nor is the restoration of said tissues in a flexible state as similar as the state of live tissues.
Conventional temporary preservation techniques, necessary or convenient in some cases for example in the case of the transport of corpses, preservation in funeral homes before burial or in forensic institutions before an autopsy is carried out, are essentially limited to placement of corpses in refrigerating vaults, or arterial insufflation or insufflation of body cavities with formol, which does not produce a satisfactory preservation, aside from the fact that, in the cases of vaults, there are high construction, operation and maintenance costs of the refrigerating vaults. And in the case of arterial insufflation, a highly specialized technician is required.
On the other hand, in practice techniques are carried out for the preparation of anatomical samples in which formaldehyde/formol are used. Said techniques are the whitening of bones, restoration of corpses, bodies of mummified animals and parts of the same, staining of nervous tissue, flexibilization of hollow viscera, obtainment of samples of blood vessels by corrosion-reflection techniques, as well as the diaphanization of animal bodies or fetuses.
With the conventional bone whitening techniques, carried out with aggressive detergents, the result does not tend to be totally satisfactory in view of the fact that it is difficult to obtain uniform whitening, besides the fact that the aggressiveness of the detergents used damages the texture of the treated bone.
With the conventional techniques of restoration of animal or human corpses or parts thereof, up to now, a technique that allows flexibilization of the mummified tis

REFERENCES:
patent: 5837159 (1998-11-01), Farkas et al.
Logani et al. Skin-Tumour Promoting Activity of Methyl Ethyl Ketone Peroxide--A Potent Lipid-Peroxidizing Agent. Food Chem. Toxicol. 22(11), pp. 879-882. (Nov. 1984). Abstract Only.
Ando et al. Methyl Ethyl Ketone Peroxide Damage to Cytochrome P-450 Peroxidase Activities. Toxicol.-Appl-Pharmacol. vol. 81, No. 3, Pt. 1, Dec. 1985. pp. 517-524. Abstract Only.
Spaulding et al. Chemically Induced Skin Carcinogenesis in a Transgenic Mouse Line (TG AC) Carrying a v-Ha-ras Gene. Carcinogenesis, 14(7), pp. 1335-1341. (Jul. 1993).

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