Compositions containing biologically active silicon

Details Compositions containing biologically active silicon Compositions containing biologically active silicon

1998-03-24

1999-12-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424433, 424436, 424400, 514 63, C07F 702, C07F 708, C07F 718, A61K 31695, A61K 748

Patent

active

060013893

ABSTRACT:
A method of treatment of osteo-articular disease which includes administering an effective amount of a pharmaceutical composition containing a compound of specified formula and an excipient to a patient in need of such treatment. The compounds of specified formula have a phosphonate group on one end and a silanol or silanol precursor on the opposite end, and can inhibit serine proteases.

REFERENCES:
patent: 3914416 (1975-10-01), Gueyne et al.
patent: 4985405 (1991-01-01), Gueyne et al.
Henrotte et al., "Le role regulateur du silicium dans la division cellulaire," 306 C.R. Acad. Sci., 525-528 (1988) with English Abstract.

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