Compositions containing biguanides and derivatives thereof as in

Details Compositions containing biguanides and derivatives thereof as in Compositions containing biguanides and derivatives thereof as in

1991-12-16

1993-10-19

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

424 49, 424 54, 514824, 514878, 514866, 514912, 514913, A61K 31155

Patent

active

052545938

ABSTRACT:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.

REFERENCES:
patent: 4758583 (1988-07-01), Cerami et al.
patent: 5100919 (1992-03-01), Ulrich et al.

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