Compositions containing bacteriophages and methods of using bact

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...

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435239, 435259, 4241841, 424 936, C12N 700, C12N 701, A01N 6300

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active

061210366

ABSTRACT:
Purified, host-specific, non-toxic, wide host range and virulent bacteriophage preparations that are effective in killing bacterial organisms in vivo are disclosed. Also disclosed are compositions containing these bacteriophages, methods of making the bacteriophage preparations and methods of treating bacterial infections using the compositions. Methods of treating bacterial infections using the compositions containing the bacteriophages in combination with conventional antibiotics also are disclosed.

REFERENCES:
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Dubos et al. 1943 Journal of Experimental Medicine vol. 78 161-168.
Levin et al. Jun. 1996 The American Naturalist 147 (6) pp. 881-898.
Rodicio et al. Sep. 1982 Journal of Bacteriology 151 (3) pp.1078-1085.
Slopek et al. 1987 Archivum Immunologiae et Therapiae Experimentalis 35 (5) 569-583.
Smith et al. 1983 Journal of General Microbiology 129 2659-2675, 1983.
Soothill 1992 Journal of Medical Microbiology 37 258-261.
Smith et al. "The control of Experimental Escherichia coli Diarrhoea in Calves by Means of Bacteriophages" Journal of General Microbiology 133:1111-1126 (1987).
Smith et al "Successful Treatment of Experimental Escherichia coli Infections in Mice Using Phage: its General Superiority over Antibiotics" Journal of General Microbiology 128:307-318 (1982).
XP 002036010 Derwent Publication Ltd. Abstract (1991).

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