Compositions containing apoptotic entities

Details Compositions containing apoptotic entities Compositions containing apoptotic entities

2006-10-17

2006-10-17

Witz, Jean C. (Department: 1651)

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Blood

C424S093700, C435S002000, C435S366000, C435S372000

Reexamination Certificate

active

07122208

ABSTRACT:
Disclosed are methods for treating and preventing neurological disorders which have a significant inflammatory component. The methods of the present invention involve extracting blood from a patient, subjecting the blood ex vivo to at least one stressor selected from the group consisting of an oxidative environment, thermal stress and UV light, and then re-administering the blood to the patient, thereby reducing inflammation.

REFERENCES:
patent: 5834030 (1998-11-01), Bolton
patent: 5980954 (1999-11-01), Bolton
patent: 6086552 (2000-07-01), Bolton
patent: 96/34613 (1996-11-01), None
patent: 00/41705 (2000-07-01), None
Kuljis et al., Minimal Cognitive Impairment, http://www.emedicine.com
euro/topic714.htm, last updated Jun. 18, 2004.
Mecocci, Journal of Alzheimer's Disease 6: 159-163 (2004).
Malfroy et al., Cellular Immunology 177: 62-68 (1997).
Bliss TV, Collingridge GL. “A synaptic model of memory: long-term potentiation in the hippocampus.”Nature. 361(6407):31-9 (1993).
Bradford MM. “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.”Anal Biochem. 72:248-54 (1976).
Green LN. “Corticosteroids in the treatment of Sydenham's chorea.”Arch. Neurol. 35(1): 53-4 (1978).
Haan EA, et al. “Protection of neocortical tissue prisms from freeze-thaw injury by dimethyl sulphoxide,”J. Neurochem. 37(1):243-6 (1981).
Kedziora J, et al. “Down's syndrome: a pathology involving the lack of balance of reactive oxygen species.”Free Radic. Biol. Med.. 4(5): 317-30 (1988).
Kouamé N, et al. “Vasocare-therapy attenuates telemetered temperature responses to stress in SHR.” 9thInternational Symposium on SHR and Cardiovascular Genetics, Montreal, Canada, #P-136, Nov. 13-16, 1997. (abstract).
Layton ME, et al. “Reactive oxidant species in piriform cortex extracellular fluid during seizures induced by systemic kainic acid in rats.”J. Mol. Neurosci13(1-2): 63-8 (1999).
Lebel CP, et al. “Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress.”Chem Res Toxicol. 5(2):227-31 (1992).
Maroney AC, et al. “Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway.”J Neurosci. 18(1):104-11 (1998).
Martin DSD, et al. “A diet enriched in a-lipoic acid reverses the age-related compromise in antioxidant defenses in rat cortical tissue.”Nutritional Neuroscience3: 193-206 (2000).
Mcgahon B, et al. “The synergism between metabotropic glutamate receptor activation and arachidonic acid on glutamate release is occluded by induction of long-term potentation in the dentate gyrus.”Neuroscience. 72(3):847-55 (1996).
Mogi M, et al. “Interleukin (IL)-1b, IL-2, IL-4, IL-6 and transforming growth factor-a levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease.”Neurosci Lett. 211(1):13-6 (1996).
Murray CA, et al. “Evidence that increased hippocampal expression of the cytokine interleukin-1b is a common trigger for age- and stress-induced impairments in long-term potentiation.”J Neurosci. 18(8):2974-81 (1998).
O'Donnell E, et al. “Age-related impairment in LTP is accompanied by enhanced activity of stress-activated protein kinases: analysis of underlying mechanisms.”Eur J Neurosci. 12(1):345-52 (2000).
Park DS, et al. “Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum
erve growth factor-deprived PC12 cells.”J Biol Chem. 271(36):21898-905 (1996).
Rabinovitch BA, et al. “VasoCare™ PSCT normalizes the Th2 cell subset in scleroderma.” XII Pan-American Congress of Rheumatology, Montreal, Canada, 1998.
Schuchmann S, et al. “Increased mitochondrial superoxide generation in neurons from trisomy 16 mice: a model of Down's syndrome.”Free Radic. Biol. Med. 28(2): 235-50 (2000).
Shivji GM, et al. “The effect of VAS972 on allergic contact hypersensitivity.”J Cutan Med Surg. 4(3):132-7 (2000).
Tenneti L, et al. “Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons.”J Neurochem. 71(3):946-59 (1998).
Trembovler V , et al. “Antioxidants attenuate acute toxicity of tumor necrosis factor-alpha induced by brain injury in rat.”J. Interferon Cytokine Res. 19(7): 791-5 (1999).
Vereker E, et al. “Lipopolysaccharide inhibits long term potentiation in the rat dentate gyrus by activating caspase-1.”J Biol Chem. 275(34):26252-8 (2000).
Vereker E, et al. “The inhibitory effect of interleukin-1b on long-term potentiation is coupled with increased activity of stress-activated protein kinases.”J Neurosci. 20(18):6811-9 (2000).
Wildburger R, et al. “Post-traumatic dynamic changes in the antibody titer against oxidized low density lipoproteins.”Wien Klin Wochenshr. 112(18) 798-803 (2000).
Database Medline [Online] US National Library of Medicine (NLM), Bethesda, MD, US; 1998, Sagara Y: “Cellular mechanisms of resistance to oxidative stress,” Database accession No. NLM9641255.
Database Medline [Online] US National Library of Medicine (NLM), Bethesda, MD, US; 1995, Rogers J: “Inflammation as a pathogenic mechanism in Alzheimer's disease,” Database accession No. NLM7763341.
Database Medline [Online] US National Library of Medicne (NLM), Bethesda, MD, US; 1999, Hirsch E C: “Mechanism and consequences of nerve cell death in Parkinson's disease,” Database accession No. NLM10370907.
Database Medline [Online] US National Library of Medicine (NLM), Bethesda, MD, US; 2003, Beal M F: “Mitochondria, oxidative damage and inflammationin Parkinson's disease,” Database accession No. NLM12846981.

Affiliated with

Also associated with

Rating

Compositions containing apoptotic entities does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions containing apoptotic entities, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions containing apoptotic entities will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3688067