Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-10-17
1999-03-02
Lambkin, Deborah C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514617, 514625, A61K 3116, A61K 31165
Patent
active
058772219
ABSTRACT:
Novel derivatives of 1-aminoindan and their salts are described. Optically active 1-aminoindan derivatives are prepared by reacting a N-benzyl analog of the desired compound with an enantiomer of mandelic acid. Parkinson's disease, dementia, epilepsy, convulsions, or seizures are treated by administering a compound of the formula: ##STR1##
REFERENCES:
patent: 2573645 (1951-10-01), Kerwin et al.
patent: 2982783 (1961-05-01), Schenck et al.
patent: 3060091 (1962-10-01), Witkin et al.
patent: 3123642 (1964-03-01), Temple et al.
patent: 3178478 (1965-04-01), Huebner
patent: 3201470 (1965-08-01), Huebner
patent: 3253037 (1966-05-01), Huebner
patent: 3308157 (1967-03-01), Robertson et al.
patent: 3637740 (1972-01-01), Sarges
patent: 3704323 (1972-11-01), Krapcho
patent: 3709996 (1973-01-01), Gittos et al.
patent: 3751420 (1973-08-01), Hauck et al.
patent: 3991207 (1976-11-01), Sarges et al.
patent: 4096173 (1978-06-01), Molloy
patent: 4128666 (1978-12-01), Bondinell et al.
patent: 4132737 (1979-01-01), Molloy
patent: 4134997 (1979-01-01), Cannon et al.
patent: 4172093 (1979-10-01), Goransson-Dahlander et al.
patent: 4632939 (1986-12-01), Beedle et al.
patent: 4788130 (1988-11-01), Oshiro et al.
patent: 4833273 (1989-05-01), Goel
patent: 4873241 (1989-10-01), Napier et al.
patent: 5071875 (1991-12-01), Horn et al.
patent: 5118704 (1992-06-01), Minaskanvan et al.
patent: 5153225 (1992-10-01), Schohe et al.
patent: 5225596 (1993-07-01), Carlsson et al.
patent: 5286747 (1994-02-01), Arvidlsson et al.
patent: 5389687 (1995-02-01), Schaus et al.
patent: 5569669 (1996-10-01), Guillaumet et al.
patent: 5646188 (1997-07-01), Gilad et al.
patent: 5708018 (1998-01-01), Haadsma-Sevnssonet et al.
Oshiro, Y., et al., "Novel Cerebroprotective Agents with Central Nervous System Stimulating Activity. 1. Synthesis and Pharmacology of 1-Amino-7-hydroxyindan Derivatives" J. Medicinal Chem. (1991) 34(7): 2004-2013.
J. Pharm. Exp. Ther., 180:523-530, 1975.
Horn et al, "Steric Requirements for Catecholamine Up-take by Rat Brain Synapsomes Studies with Rigid Analogs of Amphetamine", J. Pharm. Exp. Ther., vol. 180, pp. 523-530, 1972.
Martin et al (I), "Potential anti-Parkinson drugs designed by receptor mapping", CA78:119099 from J.Med.Chem., vol. 16,No. 2, pp. 147-150, 1973.
Martin et al (II), "Discriminant Analysis of the Relationship Between Physical Properties and Inhibition of MAO by Aminotetralins and Aminoindans", J. Mod. Chem., vol. 17, No. 4, pp. 409-413, 1974.
Merck Manual, 15th Edition, pp. 1030-1033, 1987.
Cohen Sasson
Finberg John P. M.
Herzig Yaacov
Levy Ruth
Sterling Jeff
Lambkin Deborah C.
Technion Research and Development Foundation Ltd.
Teva Pharmaceutical Industries Ltd.
White John P.
LandOfFree
Compositions containing and methods of using 1-aminoindan and de does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions containing and methods of using 1-aminoindan and de, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions containing and methods of using 1-aminoindan and de will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-423428