Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds hapten – hapten-carrier complex – or...
Patent
1977-09-26
1979-05-15
Fagelson, Anna P.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds hapten, hapten-carrier complex, or...
2603975, 424 99, 424100, 424105, 424238, 424239, 424240, 424241, 424242, 424243, A61K 3100, A61K 3156, A61K 3158, A61K 4700
Patent
active
041548205
ABSTRACT:
A new and remarkably stable synthesized conjugated estrogen composition comprising one or more selected alkali metal synthetic conjugated estrogen sulfate salts and an effective amount of one or more suitable antioxidants has been found for use in novel and stable therapeutic preparations of a pH of not less than about 7 which are adapted to relieve, inter alia, complaints occurring in the menopausal syndrome and other female complaints. Preferably, the steroids are selected from the sodium and potassium salts of the group consisting of estrone, equilin, 17.alpha.-dihydroequilin, and mixtures or conjugates thereof. Most preferably, the preparations are so formulated so that sodium estrone sulfate, sodium equilin sulphate, and 17.alpha.-dihydroequilin sodium sulphate as conjugated estrogens are present in a weight ratio of about 6:3:1, respectively and administered in tablets containing 0.625 mg, 1.25 mg, or 2.5 mg of total conjugated estrogens.
REFERENCES:
patent: 2324348 (1943-07-01), Anderson
patent: 2834712 (1958-05-01), Beall
patent: 3644618 (1972-02-01), Holden
patent: 3666865 (1972-05-01), Ludwig
patent: 3674869 (1972-07-01), Ludwig
Modern Drug Ency. & Therap. Index, 9th Ed., 1963, pp. 280-281, 517-521, 1112-1114, 1376, 1389-1390, 1441.
Smith, Chem. Abs., vol. 41, 1947, p. 7484e.
Nazir, Chem. Abs., vol. 56, 1962, p. 2743i-2744a.
Kaufman, Chem. Abs., vol. 58, 1963, pp. 12785h-12786a.
Strenkovskaya, Chem. Abs., vol. 73, 1970, Ab. No. 18447t.
Schroeter, J. Pharm. Sci., vol. 50, Nov. 1961, pp. 891-900.
Smith, J. of Endocrin., vol. 5, 1947, pp. 152-157.
Merck Index, Merck & Co., Rahway, N.J., 7th Ed., 1960, p. 537.
Akzona Incorporated
Fagelson Anna P.
Falk Robert H.
Wendel Charles A.
Young Francis W.
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