Compositions containing a disintegrin and methods for its use in

Details Compositions containing a disintegrin and methods for its use in Compositions containing a disintegrin and methods for its use in

1996-11-08

1998-09-29

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3800, A61K 3816, C07K 1400

Patent

active

058146091

ABSTRACT:
A disintegrin is employed as an active agent for treatment of various conditions, particularly cancer to prevent metastasis. In a particular embodiment contortrostatin is employed to prevent metastasis in breast cancer patients.

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Knudsen et al. Exper. Cell Research, 179:42-49, Jan. 1988.
Gehlsen et al. J. CELL Biol. 106:925-30, Mar. 1988.
Humphries et al. J. Clin. Investigation, 81, 7820790, Mar. 1988.
Dedhar et al. J. Cell. Biol. 105: 1175-1182, Mar. 1987.
Krontis. J. Molecular and cellular biology of acncer. In: Internal Medicine, 4th Edition, Editor-In-Chief Jay Stein, Chapters 71-72, pp. 699-715, Feb. 1992.
Brooks, P. C., et al., "Requirement of Vascular Integrin .alpha..sub.v .beta..sub.3 for Angiogenesis", Science, 264:569 (1994).
Brooks, P.C., et al., "Integrin .alpha..sub.v .beta..sub.3 Antagonists Promote Tumor Regression by Inducing Apoptosis of Angiogenic Blood Vessels", Cell, 79:1157 (1994).

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