Compositions containing a 4-quinolone derivative complexed with

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514250, 514316, 514320, 514321, 514912, 514913, A61K 31495, A61K 3150, A61K 31445

Patent

active

053045599

ABSTRACT:
The present invention concerns a fluid pharmaceutical composition intended to be brought into contact with a physiological fluid, characterized in that it contains, as active principle, at least one 4-quinolone derivative complexed with a divalent metal ion selected from Cu.sup.++, Zn.sup.++ and Mg.sup.++, the said complex being in the form of particles of a size compatible with parenteral or ophthalmic administration, in suspension in a fluid dispersant and not being subject to a crystalline growth phenomenon during storage of the said composition; the invention also provides a process for preparing a pharmaceutical composition of this type.

REFERENCES:
patent: 4861760 (1989-08-01), Mazuel et al.
Nakano et al., Chem. Pharm. Bull. 26(5) 1505-1510 (1978).

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