Compositions comprising ONCONASE (TM) and STELAZINE (TM) or TAMO

Details Compositions comprising ONCONASE (TM) and STELAZINE (TM) or TAMO Compositions comprising ONCONASE (TM) and STELAZINE (TM) or TAMO

1994-08-01

1996-07-30

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435199, 530350, 514 12, A61K 3843, C12N 922

Patent

active

055409253

ABSTRACT:
A pharmaceutical to be sold under the ONCONASE trademark, as described in pending commonly owned application application Ser. No. 07/436,141 filed Nov. 13, 1989 is combined with other drugs sold under the trademarks TAMOXIFEN and STELAZINE. The combination of ONCONASE with TAMOXIFEN has unexpected bioactivity in vitro against ASPC-1 human pancreatic adenocarcinoma cells and the combination of ONCONASE with STELAZINE has unexpected bioactivity in vitro against A-549 human lung carcinoma cells.

REFERENCES:
patent: 4195017 (1980-03-01), Bogoch
patent: 4882421 (1989-11-01), Shogen et al.
patent: 4888172 (1989-12-01), Szebenyi et al.
Embase Abstract No.: 93284537. Phase I human clinical trial of ONCONASE (R) (P-30 protein) administered intravenously on a weekly schedule in cancer patients with solid tumors, Mikulski S. M.; Grossman A. M.; Carter P. W.; Shogen K.; Costanzi J. J., Int. J. ONCOL. (Greece), 1993, Mar. 1 (57-64).
McClay et al. 1988. Semin Oncol. 15(6):569-577 (Abstract Only), Dialog File 155 accession No. 8908 4596.
Hird et al. 1990. Genes and Cancer, John Wiley & Sons, Ltd., Corney et al. (eds). pp. 183-189, N.Y.
Mikulski et al. May 1990. Cell Tissue Kinet. 23:237-246.
Ardelt et al. 1991. J. Biol. Chem. 266(1):245-251.

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