Compositions comprising ONCONASE (tm) and lovastatin

Details Compositions comprising ONCONASE (tm) and lovastatin Compositions comprising ONCONASE (tm) and lovastatin

1992-07-28

1997-01-21

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

530350, A61K 3754, C07K 1400

Patent

active

055957340

ABSTRACT:
A pharmaceutical known by the trademark ONCONASE, as described in pending commonly owned application application number 07/436,141 filed Nov. 13, 1989, is combined with two forms of another drug known as Lovastatin. The combination of ONCONASE with Lovastatin has unexpected bioactivity in vitro against ASPC-1 human pancreatic adenocarcinoma cells, A-549 human lung carcinoma cells and HT-520 human squamous cell lung carcinoma cells.

REFERENCES:
patent: 4231938 (1980-11-01), Monaghan et al.
patent: 4882421 (1989-11-01), Shogen et al.
patent: 5082650 (1992-01-01), Folkers et al.
Abstract, Dialog File 155 accessior No. 90291445 of Mikulski et al, May 1990. Cell Tissue Kinet. 23(3):237-246.
Abstract, Embase No. :92250984 of Mikulski et al. Aug. 1992, Br. J. Cancer. 66(2):304-310.

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