Compositions comprising leukocyte-derived growth factors and met

Details Compositions comprising leukocyte-derived growth factors and met Compositions comprising leukocyte-derived growth factors and met

1995-04-04

1998-09-08

Kemmerer, Elizabeth C.

Drug, bio-affecting and body treating compositions

Lymphokine

514 2, 514 8, 514 12, 514 21, A61K 3819, A61K 3818, A61K 3816

Patent

active

058041761

ABSTRACT:
A gene encoding a leukocyte-derived growth factor (LDGF) has been isolated, cloned and sequenced. LDGF is believed to correspond to a PDGF-like monocyte-derived growth factor with chemotactic activity which is found in human wound fluid. Protease-resistant and other analogues of LDGF, as well as recombinant LDGF of native amino acid sequence, may now be produced by gene expression in transformed hosts.

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Carrico et al., "Biology of Wound Healing," Surgical Clinics of North America, vol. 64, No. 4, pp. 721-733 (1984).
Ford et al., "Characterization of Wound Cytokines in the Sponge Matrix Model," Arch Surg, vol. 124, 1422-1428 (1989).
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Ford et al, Arch Surg 124, 1989 pp. 1422-1428.
Carrico et al, Surgical Clin of N. Am. 64(4) 1984, pp. 721-733.

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