Compositions comprising large and small binding fragments of...

Details Compositions comprising large and small binding fragments of... Compositions comprising large and small binding fragments of...

2004-06-03

2009-11-17

Navarro, Mark (Department: 1645)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C424S135100, C424S141100, C424S150100

Reexamination Certificate

active

07618625

ABSTRACT:
A pharmaceutical composition comprising (i) a first specific binding agent selected from an antibody or a large binding fragment of an antibody which specifically binds a target toxin, and (ii) a second specific binding agent which comprises a small binding fragment of an antibody which binds said toxin. The compositions are used in the treatment of toxin poisoning, for example following exposure to toxins such as Botulinum toxins.

REFERENCES:
patent: 2005/0042775 (2005-02-01), Pomato et al.
Stockwin et al, The role of therapeutic antibodies in drug discovery, 2003, Biochem Soc Trans, vol. 31, p. 433-436.
Habermann et al (Med. Microbiol. Immunol. Vol. 161, pp. 203-210, 1975).
Behr, at at, ‘Anti-Carcinoembryonic antigen Antibodies versus Somatostatin Analogs in the Detection of Metastatic Medullary Thyroid Carcinoma.’Sixth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer, Supplement to Cancer, pp. 2436-2457(1997).
Hibbs, et al., ‘Experience with the Use of an Investigational F(ab′)2Heptavalent Botulism Immune Globulin of Equine Origin During an Outbreak an Outbreak of Type E Botulism in Egypt,’Clinical Infectious Diseases, 23:337-340 (1996).
Ismail, et al., ‘Pharmacokinetics of125I-Labelled IgG, F(ab')2and Fab Fractions of Scorpion and Snak Antivenins: Merits and Potential for Therapeutic Use.’Toxicon, 36(11):1523-1528 (1998).
Mayers, etal., ‘Anti-immunoglobulin Responses to IgG,F(ab')2and Fab Botulinum Antitoxins in Mice,’Immunopharmacology and Immunotoxicology, 25(3):397-408 (2003).
Mayers, et al., ‘Antitoxin therapy for botulinum Intoxication,’Reviews in MedicalMicrobiology, 12(1):29-37 (2001).
Muller, et al., ‘Phage-displayed and soluble mouse scFv fragments neutralize rabies virus,’Journal of Virological Methods, 87:221.233(1997).
Steele, etal., ‘Further Evidence for Cross-Linking as a Protective Factor in Experimental Cholera: Properties of Antibody Fragments,’The Journal of Infectious Diseases,132(2):175-180 (1975).
Vassilev, at al., ‘Protective Activity of Two Human Intravenous immunoglobulin Preparations in Experimental Infection with an Encapsulated Staphylococcus Aureus Strain,’Acta Microblologica Hungarica, 34(2):139-145 (1987).
Vaz, et al., ‘Higher protective activity of Fab fragment compared to F(ab')2 and IgG on experimental tetanus,’Mircen Journal of Appl. Microbial.&Biotech., 4(3):339-348 (1988).

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