Compositions comprising inhibitors of IMPDH enzyme

Details Compositions comprising inhibitors of IMPDH enzyme Compositions comprising inhibitors of IMPDH enzyme

2011-05-17

2011-05-17

Weddington, Kevin (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S048000, C514S374000

Reexamination Certificate

active

07943593

ABSTRACT:
The present invention relates to compositions comprising an apoptosis inducing anti-cancer agent and an IMPDH inhibitor. This invention also relates to methods for inducing apoptosis and for treating tumors and cancers in mammals.

REFERENCES:
patent: 4210745 (1980-07-01), Montgomery
patent: 4357324 (1982-11-01), Montgomery et al.
patent: 6498178 (2002-12-01), Stamos et al.
patent: WO 97/40028 (1997-10-01), None
patent: WO 00/56331 (2000-09-01), None
Kaufmann, et al. Minireview: Induction of Apoptosis by Cancer Chemotherapy, Exper. Cell. Research, vol. 256, pp. 42-49, (2000).
Jain, et al., “VX-944:. A Specific, Reversible IMPDH Inhibitor with Potent Anti-Proliferative Effects in Human Tumor Cell Lines Derived from Hematological Malignancies,” Blood, vol. 100, No. 11, (2002).
Jain, et al., “VX-944, A Novel Inosine Monophosphate Dehydrogenase Inhibitor, Induces Apoptosis and Decreases Proliferation of Lymphoid and Myeloid Cells Derived from Hematological Malignancies”, Blood, vol. 102, No. 11, (2003).

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