Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1995-06-05
1997-07-01
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514715, 514717, 514824, 514866, A61K 3119, A61K 31075
Patent
active
056439512
ABSTRACT:
Methods for the treatment of metabolic and/or cardiovascular disorders comprising administering to a human in need thereof a therapeutically effective amount of a composition comprising dichloroacetic acid or a pharmaceutically acceptable salt or derivative thereof and a pharmaceutically acceptable mixture of carbonate and bicarbonate ions, the weight ratio of dichloroacetic acid, derivative or salt thereof to the mixture of carbonate and bicarbonate ions being in the range of from about 100:1 to about 0.01:1. Also disclosed are pharmaceutical compositions in unit dosage form adapted for administration to a human for the treatment of metabolic and/or cardiovascular disorders comprising a therapeutically effective amount of a composition comprising dichloroacetic acid or a pharmaceutically acceptable salt or derivative thereof and a pharmaceutically acceptable mixture of carbonate and bicarbonate ions, the weight ratio of dichloroacetic acid, derivative or salt thereof to the mixture of carbonate and bicarbonate ions being in the range of from about 100:1 to about 0.01:1; and a pharmaceutically acceptable carrier therefor.
REFERENCES:
CA 108: 143192y, Dimlich et al., 1988.
Bersin et al., "Improved Hemodynamic Function During Hypoxia with Carbicarb*, A New Agent for the Management of Acidosis, Circulation"77(1), p. 227-233, 1988.
CA103:171834z, Graf et al., 1985.
Bersin Robert M.
Stacpoole Peter W.
Clarke Dennis P.
Jordan Kimberly
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