Compositions comprising C-13 alkoxyether macrolide compounds...

Details Compositions comprising C-13 alkoxyether macrolide compounds... Compositions comprising C-13 alkoxyether macrolide compounds...

2011-04-05

2011-04-05

Peselev, Elli (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S292000, C504S292000

Reexamination Certificate

active

07919522

ABSTRACT:
Provided is a novel ivermectin derivative and compositions for the treatment or prophylaxis of parasite infestations in mammals or birds which comprise:(A) a pharmaceutically effective amount of a 1-N-phenylpyrazole compound;(B) a pharmaceutically effective amount of an ivermectin derivative of formula (II)wherein:R14represents —(CH2)s—O—Zwherein,s is 1 or 2;Y represents —CH(OR15)—, —C(═O)— or —C(═NOR15);R15represents hydrogen, alkyl or phenyl; andR16represents —CH3or —CH2CH3;Z is alkyl, alkenyl, alkynyl, acyl, alkylalkoxy, aryl, alkanoyloxy, alkoxycarbonyl, alkenoyl, alkynoyl, or aroyl.

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Cvetovich R.J. ,et al.: “Practical Synthesis of 13-0-[(2-Methoxyethoxy)methyl]-22,23-dihydroavermectin B1 Aglycon [Dimedectin Isopropanol, MK-324] and13-epi-O-(Methoxymethyl)-22,23-dihyroavermectin B1 Aglycon [L-694,554], Flea Active Ivermectin Analogues” J. Org. Chem., vol. 62, 1997, pp. 3989-3993.

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