Compositions comprising bone morphogenic proteins and truncated

Details Compositions comprising bone morphogenic proteins and truncated Compositions comprising bone morphogenic proteins and truncated

1997-09-10

1998-12-08

Kemmerer, Elizabeth

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514 12, 424 851, 530350, 530351, 530397, 530399, 530300, 530324, C07K 14495, C07K 1451, C07K 14635, A61K 3817

Patent

active

058469311

ABSTRACT:
Compositions of proteins with chondrocyte and cartilaginous tissue inducing activity, as well as method of using those compositions, are disclosed. The compositions comprise one or more proteins of the transforming growth factor-.beta. (TGF-.beta.) superfamily of proteins, particularly bone morphogenetic proteins (BMPs), in combination with parathyroid hormone related polypeptide (PTHrP) or an equivalent PTH-like polypeptide. The compositions and methods are useful in the treatment of osteoarthritis, cartilage defects and in related tissue repair.

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