Compositions comprising a peptide inhibitor of nuclear protein t

Details Compositions comprising a peptide inhibitor of nuclear protein t Compositions comprising a peptide inhibitor of nuclear protein t

1998-05-04

1999-10-05

Carlson, Karen Cochrane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 530350, 530300, C07K 1400

Patent

active

059624159

ABSTRACT:
Novel compositions of immunosuppressants, such as cyclosporin, and polypeptide inhibitors of cytoplasmic protein nuclear translocation are disclosed. The compositions have, in addition to at least one immunosuppressant, at least one polypeptide inhibitor of nuclear translocation that has a signal sequence and at least one, preferably two, nuclear localization sequences. The compositions are useful as immunosuppression, antiviral and antitumor agents, preferably to prevent rejection of transplanted organs or tissue.

REFERENCES:
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Journal of Heart and Lung Transplantation vol. 14, No. 1, Part 2, Abstracts S51.

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