Compositions comprising a biocompatible gas and a polymer for ma

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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424 936, 424 952, 436173, 514 6, 514 54, 514 57, A61B 5055

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active

056815425

ABSTRACT:
Novel contrast media for use in magnetic resonance imaging are described. Such contrast media are comprised of biocompatible polymers either alone or in admixture with one or more contrast agents such as paramagnetic, superparamagnetic or proton density contrast agents. Additionally, the polymers or polymer and contrast agent admixtures may be mixed with one or more biocompatible gases to increase the relaxivity of the resultant preparation, and/or with other components. In a preferable embodiment, the contrast medium is hypoosmotic.

REFERENCES:
patent: 4069306 (1978-01-01), Rothman
patent: 4225592 (1980-09-01), Lakatos et al.
patent: 4586511 (1986-05-01), Clark, Jr.
patent: 4647447 (1987-03-01), Gries et al.
patent: 4678667 (1987-07-01), Meares et al.
patent: 4719098 (1988-01-01), Weinmann et al.
patent: 4729892 (1988-03-01), Beall
patent: 4775522 (1988-10-01), Clark, Jr.
patent: 4804529 (1989-02-01), Bardy et al.
patent: 4822594 (1989-04-01), Gibby
patent: 4826673 (1989-05-01), Dean et al.
patent: 4830849 (1989-05-01), Osterholm
patent: 4838274 (1989-06-01), Schweighardt
patent: 4849210 (1989-07-01), Widder
patent: 4865836 (1989-09-01), Long, Jr.
patent: 4871716 (1989-10-01), Longo et al.
patent: 4898734 (1990-02-01), Mathiowitz et al.
patent: 4925648 (1990-05-01), Hansen et al.
patent: 4927623 (1990-05-01), Long, Jr.
patent: 4933441 (1990-06-01), Gibby
patent: 4963344 (1990-10-01), Gries et al.
patent: 4986980 (1991-01-01), Jacobsen
patent: 4996041 (1991-02-01), Arai et al.
patent: 5000960 (1991-03-01), Wallach
patent: 5021236 (1991-06-01), Gries et al.
patent: 5094848 (1992-03-01), Brixner
patent: 5174987 (1992-12-01), Takaichi et al.
patent: 5186924 (1993-02-01), Fishman
patent: 5215680 (1993-06-01), D'Arrigo
patent: 5230883 (1993-07-01), Kornguth et al.
patent: 5236694 (1993-08-01), Antich et al.
patent: 5315997 (1994-05-01), Widder et al.
Clanton et al., Radiology, vol. 149, p. 238 (1983) (abstract).
Clanton et al., Radiology, vol. 153, p. 159 (1984) (abstract).
Hahn et al., Radiology, vol. 164, pp. 37-41 (1987).
Hahn et al., Magn. Reson. Imaging, vol. 6, p. 78 (1988) (abstract).
D.M. Kean and M.A. Smith, Magnetic Resonance Imaging: Principles and Applicatioins, (Williams and Wilkins, Baltimore 1986).
Kornmesser et al., Magn. Reson. Imaging, vol. 6, p. 124 (1988) (abstract).
Laniado et al., AJR, vol. 150, pp. 817-821 (1988).
Mattrey et al., AJR, vol. 148, pp. 1259-1263 (1987).
Newhouse et al., Radiology, vol. 142(P), p. 246 (1982) (abstract).
Runge et al., Radiology, vol. 147, pp. 789-791 (1983).
Runge et al., Physiol. Chem. Phys. Med. NMR, vol. 16, pp. 113-122 (1984).
Tscholakoff et al., AJR, vol. 148, pp. 703-709 (1987).
Weinreb et al., J. Comput. Assist. Tomogr., vol. 8, pp. 835-838 (1984).
Wesbey et al., Radiology, vol. 149, pp. 175-180 (1983).
Wesbey et al., Magn. Reson. Imaging, vol. 3, pp. 57-64 (1985).
Widder et al., AJR, vol. 149, pp. 839-843 (1987).
Williams et al., Radiology, vol. 161(P), p. 315 (1986) (abstract).
Young et al., CT, vol. 5, pp. 543-547 (1981).
Bailey et al., Poly(ethylene oxide) (Academic Press, NY 1976).
Blow et al., FEBS. Lett., vol. 94, pp. 305-310 (1978).
Laurent, Eur. J. Biochem., vol. 21, pp. 498-506 (1971).
Pilgrimm et al., Chemical Abstracts, vol. 112, p. 380, No. 51778y (1990).
S. Deiana et al., Inorganica Chemica Acta, vol. 46, pp. 249-253 (1980).
S. Deiana et al., Interaction of Transition-Metal With Polygalacturonic Acid: A Potentiometric Study (Elsevier Scientific Publishing Co., Amsterdam, 1982).
Atkins et al., Biopolymers, vol. 12, pp. 1865-1878 (1973).
Atkins et a., Biopolymers, vol. 12, pp. 1879-1887 (1973).
Mihashi, Pharmaceutical J., vol. 81, pp. 1000-1002 (1961).
Guyton, Arthur C., Textbook of Medical Physiology, Chapters 4 and 33, 6th Ed., W.B. Saunders Company, Philadelphia, PA (1981).
Braybrook et al., "Effect of PH on the Nuclear Magnetic Resonance Relaxivity . . . ", Drug Design and Delivery, vol. 4, pp. 93-95 (Harwood Academic, Great Britain 1989).

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