Drug – bio-affecting and body treating compositions – Penetrant or absorbent – Topical application
Patent
1986-04-23
1988-07-05
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Penetrant or absorbent
Topical application
548521, 548546, 514946, 514919, 514448, 514441, 514212, 514326, 514315, 502167, 71 88, 71 94, 71 95, 8564, 540524, 540525, 540529, 540530, 540531, 546193, 546194, 546281, 546265, 546262, 546290, C07D22310, A61K 3155
Patent
active
047555351
ABSTRACT:
This invention provides compositions comprising a physiologically-active agent and an azacycloalkene having at least one double bond in the ring and of the general formula ##STR1## wherein X and Y, each, may represent sulfur, oxygen or two hydrogen atoms, A is a straight or branched chain, divalent aliphatic radical having from 0 to 2 double bonds; R' is selected from the group consisting of H, a lower alkyl group having 1-4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkylformyl; m is 3-7; q is 2m-2x, wherein x equals the number of double bonds in the lactam ring and may be 1, 2 or 3; and R is --CH.sub.3, ##STR2## wherein R" is H or halogen in an amount effective to enhance the penetration of the physiologically-active agent through the skin or other membrane of the body of an animal.
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Rothe and Toth, "Chem. Bernchte" Band 99 No. (12), pp. 3820-3829 (1966).
English Abstract of Spanish Patent Application ES 549,688, Mar. 16, 1986.
Minaskanian Gevork
Peck James V.
Bond Robert T.
Bostich June M.
Nelson Research & Development Co.
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