Compositions comprising 1-substituted azacycloalkanes

Details Compositions comprising 1-substituted azacycloalkanes Compositions comprising 1-substituted azacycloalkanes

1990-01-22

1991-08-27

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540529, 548530, 548545, 514946, 514947, C07D22310, A61K 3155

Patent

active

050434411

ABSTRACT:
This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula ##STR1## wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents two hydrogen atoms, both X and Y represent oxygen or sulfur and when Z represents oxygen or sulfur at least one of X and Y must represent oxygen or sulfur; m is 2-6; R' is H or a lower alkyl group having 1-4 carbon atoms; n is 0-17 and R is --CH.sub.3, ##STR2## wherein R" is H or halogen in an amount effective to enhance the penetration of the physiologically-active agent through the skin or other membrane of the body of an animal.

REFERENCES:
patent: 2915430 (1959-12-01), Taber
Scelia et al., "J. Applied Polymer Science", vol. 11, pp. 1299-1313 (1967).
Falbe et al., "Chem Berichte", vol. 95, pp. 2680-2687, (1962).

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