Compositions based on aminoacids, suitable for the treatment...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S561000, C514S562000, C514S567000

Reexamination Certificate

active

07902250

ABSTRACT:
Compositions based on amino acids are described, in particular for oral or parenteral use, suitable for treating heart insufficiency.The compositions according to the invention comprise up to 75% of the branched chain amino acids leucine, isoleucine and valine, as active ingredients.Preferably, the compositions also comprise, as further active ingredients, up to 50% of threonine and lysine.Other essential amino acids are preferably also provided (in particular methionine, phenylalanine, histidine, triphtophan) as well as non essential amino acids (in particular tyrosine and/or cyst(e)ine—i.e. cystine and cyst(e)ine).Other amino acids can be added, provided that their sum is in a percentage being lower than 20% with respect to the other active ingredients, and less than 10% for each single amino acid.

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M.B. Peterson et al.: “Protein and Free Amino-Acid Metabolism in the Failing Canine Heart”, Dhalla, N.S. (ED) Recent Advances in Studies on Cardiac Structure and, vol. 1973, No., pp. 615-623, XP001037339, University Park Press,: Baltimore, MD, U.S.A.,; London, England), see p. 618-619: Protein synthesis.

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