Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1988-05-13
1989-06-06
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424443, 424444, 424445, 424422, A61L 1503
Patent
active
048370240
ABSTRACT:
The healing of a surface wound is promoted by contacting the wound surfaces with a suspension of particles of collagen and a glycosaminoglycan that is chemotactic of fibroblasts and/or endothelial cells. Typical glycosaminoglycans that exhibit the desired chemotaxis are heparin, heparan sulfate, and alginate. Two or more glycosaminoglycans can be present in the suspensions. Collagen and glycosaminoglycan are present as a dry powdered suspension of particles. Preferably, collagen is present in the suspension in the order of 7-10 mg/ml; while the glycosaminoglycan is present in much lower concentrations, e.g., 250-350 .mu.g/ml. Application of the collagen/glycosaminoglycan suspension to open wounds greatly increases the rate of healing.
The invention includes, an article, useful in the therapy for surface wounds, comprising the suspension of particles on a gauze, bandage tape or the like.
REFERENCES:
patent: 4233360 (1980-11-01), Luck et al.
patent: 4505266 (1985-03-01), Yannas
patent: 4578079 (1986-03-01), Luoslahti
patent: 4605413 (1986-08-01), Urry
Horne T. R.
Page Thurman K.
The Regents of the University of California
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