Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – N-c doai
Patent
1999-08-23
2000-07-11
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
N-c doai
514479, 514922, 607 9, 607 10, 607 11, 607 16, 607 27, 607 28, 607 30, 600 16, 600 17, 600 18, 604507, 604508, 604509, 604510, 604 96, 604272, 604523, 604532, A01N 4710, A61N 118, A61N 120, A61N 122, A61N 124
Patent
active
060873949
ABSTRACT:
Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a .beta.-blocker are provided, wherein the .beta.-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing system, thereby to maintain the patient's blood circulation. The electrical pacing then is selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and compositions advantageously may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.
REFERENCES:
patent: 3241556 (1966-03-01), Zacouto
patent: 3640269 (1972-02-01), Delgado
patent: 3797485 (1974-03-01), Urquart
patent: 4166470 (1979-09-01), Neumann
patent: 4230119 (1980-10-01), Blum
patent: 4248214 (1981-02-01), Hannah et al.
patent: 4309776 (1982-01-01), Berguer
patent: 4377704 (1983-03-01), Gero et al.
patent: 4404971 (1983-09-01), LeVeen et al.
patent: 4445892 (1984-05-01), Hussein et al.
patent: 4459309 (1984-07-01), Ciou
patent: 4562596 (1986-01-01), Kornberg
patent: 4573966 (1986-03-01), Weikl et al.
patent: 4581017 (1986-04-01), Sahota
patent: 4605399 (1986-08-01), Weston et al.
patent: 4661509 (1987-04-01), Gordon et al.
patent: 4673563 (1987-06-01), Berne et al.
patent: 4736024 (1988-04-01), Della Valle et al.
patent: 4771777 (1988-09-01), Horzewski et al.
patent: 4827906 (1989-05-01), Robicsek et al.
patent: 4857552 (1989-08-01), Rosenberg et al.
patent: 4923457 (1990-05-01), Ellingsen
patent: 4935004 (1990-06-01), Cruz
patent: 4962095 (1990-10-01), Grover et al.
patent: 5087243 (1992-02-01), Avitall
patent: 5095903 (1992-03-01), DeBellis
patent: 5096929 (1992-03-01), Chiesi et al.
patent: 5116851 (1992-05-01), Krapcho et al.
patent: 5124326 (1992-06-01), Mutschler et al.
patent: 5139789 (1992-08-01), Baumgarten
patent: 5152277 (1992-10-01), Honda et al.
patent: 5162374 (1992-11-01), Mulieri et al.
patent: 5176638 (1993-01-01), Michael
patent: 5182102 (1993-01-01), DeSantis, Jr. et al.
patent: 5229127 (1993-07-01), McKinzie
patent: 5287861 (1994-02-01), Wilk
patent: 5290766 (1994-03-01), Choong
patent: 5312344 (1994-05-01), Grinfeld et al.
patent: 5320604 (1994-06-01), Walker et al.
patent: 5356427 (1994-10-01), Miyata et al.
patent: 5425705 (1995-06-01), Evard et al.
patent: 5428039 (1995-06-01), Cohen
patent: 5433700 (1995-07-01), Peters
patent: 5442053 (1995-08-01), della Valle et al.
patent: 5452733 (1995-09-01), Sterman et al.
patent: 5455229 (1995-10-01), Hahn et al.
patent: 5458574 (1995-10-01), Machold et al.
patent: 5459140 (1995-10-01), Gramer
patent: 5474783 (1995-12-01), Miranda et al.
patent: 5478309 (1995-12-01), Sweezer et al.
patent: 5506229 (1996-04-01), Dow et al.
patent: 5543419 (1996-08-01), Cross et al.
patent: 5591195 (1997-01-01), Taheri et al.
patent: 5593428 (1997-01-01), Jamshidi
patent: 5634895 (1997-06-01), Igo et al.
patent: 5651378 (1997-07-01), Matheny et al.
patent: 5735290 (1998-04-01), Sterman et al.
patent: 5873366 (1999-02-01), Chim et al.
patent: 5913876 (1999-06-01), Taylor et al.
Acuff, T.E. et al., "Minimally invasive coronary artery bypass grafting" Ann. Thorac. Surg. 61:135-137 (1996).
Addetia et al., "Perfusion in cardioplegia: an experimental study" Canadian J. Surg. 23(2):146-150 (1980).
Agnarsson et al., "Carbachol depolarizes and accelerates pacemaker activity in the sinoatrial node of chicks treated with pertussis toxin" J. Pharmacol. Exp. Ther. 247(1):150-155 (1988).
American Hospital Formulary Service, "Motics" AHFS Drug Information 52(20):2167-2176 (1997).
Bachelard et al., "Regional haemodynamic effects of carbachol injected into the hypothalamic paraventricular nuclei of conscious, unrestrained rats" Neuropharmacology 33(6):769-788 (1994).
Backman et al., "Different properties of the bradycardia produced by neostigmine and edrophonium in the cat" Can. J. Anaesth. 43(7):731-740 (1996).
Backman et al., "Mechanism of the bradycardia produced in the cat by the anticholinesterase neostigmine" J. Pharmacol. Exp. Ther. 265(1):194-200 (1993).
Backman et al., "Neostigmine decreases heart rate in heart transplant patients" Can J. Anaesth. 43(4):373-378 (1996).
Badeer et al., "Factors affecting pulsus alternans in the rapidly driven heart and papillary muscle" Am. J. Physiology 213(5):1095-1101 (1967).
Baker, A.B. et al., "Intentional asystole during endoluminal thoracic aortic surgery without cardiopulmonary bypass" Br. J. Anaesth. 78:444-448 (1997).
Beal, "Changes in renal haemodynamics and electrolyte excretion after intraventricular infusion of carbachol in conscious sheep" Quarterly Journal of Experimental Physiology 65:159-171 (1980).
Bel et al., "Inhibition of the pacemaker current: a bradycardic therapy for off-pump coronary operations" Ann. Thorac. Surg. 66:148-152 (1998).
Benetti, F.J. and Ballester, C., "Use of thoracoscopy and a minimal thoractomy, in mammary-coronary bypass to left anterior descending artery, without extracorporeal circulation" J. Cardiovasc. Surg. 36(2):159-161 (1995).
Benetti, F.J. et al., "Video assisted coronary bypass surgery" J. Card. Surg. 10:620-625 (1995).
Bjork et al., "Coronary angiography during acetylcholine-induced cardiac arrest" Acta. Soc. Med. Upsal. 71:253-262 (1966).
Bjork et al., "Coronary angiography during acetylcholine-induced cardiac arrest in patients with angina pectoris" The J. of Cardiovascular Surgery 2(1):9-19 (1961).
Broadley, "The release of a coronary vasodilator metabolite from the guinea-pig isolated perfused heart stimulated by catecholamines, histamine and electrical pacing and by exposure to anoxia" Br. J. Pharmac. 58:89-100 (1976).
Broadley, K.J. and Rothaul, A.L., "Catecholamine-induced vasodilator metabolite release from guinea-pig hearts is not due to increased myocardial activity" Pflugers Arch. 391:147-153 (1981).
Brockman et al., "Experimental open heart surgery employing hypothermia, mecholyl arrest, and carotid perfusion" Surgery 43:815-823 (1958).
Buffolo et al., "Coronary artery bypass grafting without cardiopulmonary bypass" Ann. Thorac. Surg. 61:63-66 (1996).
Bufkin et al., "Controlled intermittent asystole for non-pump cardiac surgery: Pharmacologic potentiation of vagal-induced asystole" Conference Abstract (Jan. 1998).
Burger et al., "Prevention of urinary retention after general surgery: A controlled trial of carbachol/diazepam versus alfusozine" J. Am. Coll. Surg 185:234-236 (1997).
Calafiore, A.M. et al., "Left anterior descending coronary artery grafting via left anterior small thoracotomy without cardiopulmonary bypass" Ann. Thorac. Surg. 61:1658-1665 (1996).
Carbachol (definition). Source: http://www.rxmed.com/monographs/carba2.html (Aug. 6, 1997).
Chiba et al., "Blocking of acetylcholine-induced fibrillation by use of norepinephrine into the AV node artery" The Japanese Journal of Physiology 20:560-570 (1970).
Chiba et al., "Effect of bethanecol, methacholine and carbachol on AV conduction of the dog heart" Jap. Heart J. 13(4):347-353 (1972).
Chiba et al., "In
Duke University
Krass Frederick
LandOfFree
Compositions, apparatus and methods for facilitating surgical pr does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions, apparatus and methods for facilitating surgical pr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions, apparatus and methods for facilitating surgical pr will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-542860