Compositions and therapeutic methods using morphogenic proteins

Details Compositions and therapeutic methods using morphogenic proteins Compositions and therapeutic methods using morphogenic proteins

1996-12-06

1999-09-07

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

523114, 523115, 623 16, 530353, A61F 228, A61K 3817

Patent

active

059484284

ABSTRACT:
The present invention provides pharmaceutical compositions comprising a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Methods for improving the tissue inductive activity of a morphogenic protein in a mammal using those compositions are provided. This invention also provides implantable morphogenic devices comprising a morphogenic protein and a MPSF disposed within a carrier, that are capable of inducing tissue formation in allogeneic and xenogeneic implants. Methods for inducing local tissue formation from a progenitor cell in a mammal using those devices are also provided. A method for accelerating allograft repair in a mammal using morphogenic devices is provided. This invention also provides a prosthetic device comprising a prosthesis coated with a morphogenic protein and a MPSF, and a method for promoting in vivo integration of an implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site. Methods of treating tissue degenerative conditions in a mammal using the pharmaceutical compositions are also provided.

REFERENCES:
patent: 5011691 (1991-04-01), Oppermann et al.
patent: 5108753 (1992-04-01), Kuberasampath et al.
patent: 5162114 (1992-11-01), Kuberasampath et al.
patent: 5171574 (1992-12-01), Kuberasampath et al.
patent: 5258494 (1993-11-01), Oppermann et al.
patent: 5324819 (1994-06-01), Oppermann et al.
patent: 5344654 (1994-09-01), Rueger et al.
patent: 5354557 (1994-10-01), Oppermann et al.
patent: 5459047 (1995-10-01), Wozney et al.
patent: 5461034 (1995-10-01), Rodan et al.
patent: 5484601 (1996-01-01), O'Leary et al.
patent: 5531791 (1996-07-01), Wolfinbarger, Jr.
Aspden et al., World Patent Index, 95-373534, 1995.
Abe et al., "BMP-2 and IGF-I Compete for Each Other's Ability to Induce Differentiation Either Toward Osteoblasts or Myocytes/Myotubes in a Bipotential Cell Line," American Society for Bone and Mineral Research Abstract (Sep. 1996).
Andrews, P.W., et al., "Inhibition of Proliferation and Induction of Differentiation of Pluripotent Human Embryonal Carcinoma Cells by Osteogenic Protein-1 (or Bone Morphogentic Protein-7)", Laboratory Investigation 71:243-251 (1994).
Benayahu, D., et al., "Differential Effects of Retinoic Acid and Growth Factors on Osteoblastic Markers and CD10/NEP Activity in Stromal-Derived Osteoblasts," Journal of Cellular Biochemistry 56:62-72 (1994).
Benayahu, D., et al., "PTH and 1.25(OH) Vitamin D Priming to Growth Factors Differentially Regulates the Osteoblastic Markers in MBA-15 Clonal Subpopulations," Biochemical and Biophysical Research Communications 210:197-204 (May 5, 1995).
Boden, S.D., et al., "Evaluation of a Bovine Protein in a Non-Human Primate Model of Lumbar Spinal Fusion," 42nd Annual Meeting, Orthopaedic Research Society (Feb. 19-22, 1996).
Boden, S.D., et al., "Effects of BMPs on Osteoblast Differentiation In Vitro, " 42nd Annual Meeting, Orthopaedic Research Society (Feb. 19-22, 1996).
Boden, S.D., et al., "Reversing the Inhibitory Effect of Nicotine on Spinal fusion Using an Osteoinductive Bone Protein Extract," 42nd Annual Meeting, Orthopaedic Research Society (Feb. 19-22, 1996).
Breinan, H.A., et al., "Spontaneous Regeneration of Articular Cartliage Chondral Defects in a Canine Model," 42nd Annual Meeting Orthopaedic Research Society (Feb. 19-22, 1996).
Canalis, Ernesto, et al., "Bone Morphogenetic Protein 2 Increases Insulin-like Growth Factor I and II Transcripts and Polypeptide Levels in Bone Cell Cultures," Journal of Bone and Mineral Research 9:1999-2005 (1994).
Cao, Y., et al., "Injectable Bone," 42nd Annual Meeting, Orthopaedic Research Society (Feb. 19-22, 1996).
Chen, P., et al., "Osteogenic Protein-1 Promotes Growth and Maturation of Chick Sternal Chondrocytes in Serum-free Cultures," Journal of Cell Science 108:105-114 (Jan. 1995).
Cook, Stephen D., et al., "Recombinant Human Bone Morphogenetic Protein-7 Induces Healing in a Canine Long-Bone Segmental Defect Model," Clinical Orthopaedics & Related Research 201:302-312 (Apr. 1994).
Cook, Stephen D., et al., "The Effect of Recombinant Human Osteogenic Protein-1 on Healing of Large Segmental Bone Defects," The Journal of Bone and Joint Surgery 76-A:827-838 (Jun. 1994).
Cook, Stephen D., "In Vivo Evaluation of Recombinant Human Osteogenic Protein (rhOP-1) Implants as a Bone Graft Substitute for Spinal Fusions," Spine 19:1655-63 (Aug. 1, 1994).
Cook, Stephen D., et al., "Effect of Recombinant Human Osteogenic Protein-1 on Healing of Segmental Defects in Non-Human Primates," The Journal of Bone and Joint Surgery 77-A:734-750 (May 1995).
Cunningham, B.W., et al., "Osteogenic Protein Versus Autologous fusion in th Sheep Thoracic Spine. A Comparative Endoscopic Study Using the BAK Interbody Fusion Device,"42nd Annual Meeting, Orthopaedic Research Society (Feb. 19-22, 1996).
David, S.M., et al., "Lumbar Spinal Fusion Using Recombinant Human Bone Morphogenetic Protein (rhBMP-2): A Randomized, Blinded and Controlled Study," 42nd Annual Meeting, Orthopaedic Research Society (Feb. 19-22, 1996).
Davis, C.M. et al., "Evaluation of Gene Expression Demonstrates Different Cellular Mechanisms for Repair of Femur and Jaw Fractures," 42nd Annual Meeting, Orthopaedic Research Society (Feb. 19-22, 1996).
Dean, D.D., et al., "Bone Morphogenetic Protein-2 is an Autocrine Factor for Chondrocytes in the Endochondral Pathway," 42nd Annual Meeting, Orthopaedic Research Society, (Feb. 19-22, 1996).
Djurasovic, M., et al., "Bone Morphogenetic Protein 9 (BMP-9) Stimulates Aggrecan Gene Expression and Synthesis in Articular Cartilage Explants," 42nd Annual Meeting, Orthopaedic Research Society (Feb. 19-22, 1996).
Dudley, A.T., et al., "A Requirement for Bone Morphogenetic Protein-7 During Development of the Mammalian Kidney and Eye," Genes and Development 9:2795-2807 (Nov. 1995).
Finerman, G.A.M., et al., "Interactions of Transforming Growth Factor .alpha.2 and Bone Morphogenetic Protein on Bromodeoxyuridine Inhibition of Chondrogenesis," 42nd Annual Meeting, Orthopaedic Research Society (Feb. 19-22, 1996).
Francis-West, P.H., et al., "The Effect of Overexpression of BMP-4 and GDF-5 on the Development of Limb Skeletal Elements," 42nd Annual Meeting, Orthopaedic Research Society (Feb. 19-22, 1996).
Gabbitas, Bari, et al., "Bone Morphogenetic Protein-2 Inhibits the Synthesis of Insulin-Like Growth Factor-Binding Protein-5 in Bone Cell Cultures," The Endocrine Society 136:2397-2403 (1995).
Gitelman, Stephen E., et al., "Recombinant Vgr-1/BMP-6-expressing Tumors Induce Fibrosis and Endochondral Bone Formation In Vivo," J. Cell Biol. 126:1595-1609 (1994).
Goad, D.L., et al., "Enhanced Expression of Vascular Endothelial Growth Factor in Human SaOS Osteoblast-Like Cells and Murine Osteoblasts Induced by Insulin-Like Growth Factor I," Endocrinology 137:2262-2268 (1996).
Guerne, Pierre-Andre, et al., "Growth Factor Responsiveness of Human Articular Chondrocytes: Distinct Profiles in Primary Chondrocytes, Subcultured Chondrocytes, and Fibroblasts," J. Cell. Phys. 158:476-484 (1994).
Hammerman, Marc R., "Growth Factors in Renal Development," Seminars in Nephrology 15:291-299 (Jul. 1995).
Helder, M.N., et al., "Expression Pattern of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) in Human and Mouse Development," J. Histochem. and Cytochem. 43:1035-44 (Oct. 1995).
Hentunen, T.A., et al., "Effects of Recombinant Human Osteogenic Protein-1 on the Differentiation of Osteoclast-like Cells and Bone Resorption," Biochemical and Biophysical Research Communications 209:433-443 (Apr. 17, 1995).
Hiraki, Yuji, et al., "Bone Morphogenetic Proteins (BMP-2 and BMP-3) Promote Growth and Expression of the Differentiated Phenotype of Rabbit Chondrocytes and Osteoblastic MC3T3-E1 Cells In Vitro," Journal of Bone and Mineral Research 6:1373-1385 (Dec. 1991).
Hotta, T., et al., "The Most Important Factor of Bone Formation in Osteosarcoma," 42nd Annual Meeting, Orthopaedic Research Society (Feb. 19-22, 1996).
Kawamura

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