Compositions and techniques for localized therapy

Details Compositions and techniques for localized therapy Compositions and techniques for localized therapy

2006-11-14

2006-11-14

Channavajjala, Lakshmi (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S423000

Reexamination Certificate

active

07135189

ABSTRACT:
A therapeutic medical article is provided which comprises a medical article, a precursor compound and an activator compound. The medical article is adapted, upon administration to a patient, to release the precursor compound and the activator compound such that the activator compound interacts with the precursor compound and converts the precursor compound into activated form for local delivery. Specific examples of precursor and activator compound pairs include: (a) a nitrosothiol precursor and a nitric oxide donor, (b) plasminogen and plasminogen activator, and (c) fibrinogen and thrombin.

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