Compositions and serological methods including bovine serum albu

Details Compositions and serological methods including bovine serum albu Compositions and serological methods including bovine serum albu

1975-04-08

1977-09-06

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

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Taste or smell or chemical irritation to the eye, nose, or...

2601125R, 260121, 424 8, 424 12, 424 13, 424101, 424177, C07G 700, G01N 3100, G01N 3316

Patent

active

040468712

ABSTRACT:
New serological albumin compositions are provided which have greater potentiating capabilities than existing compositions in agglutination reactions of the IgG class of immune globulins. The essential component is at least one covalently bonded serum albumin polymer. The novel polymers are those containing from two to about eight or more monomeric albumin units which are joined to each other through a covalent peptide bond. Serological compositions may be prepared by polymerization of a dilute aqueous albumin solution, quenching of the reaction, precipitation of the products as solids, dissolution of albumin solids with or without separation of polymers in physiological or isotonic solutions. The compositions are useful as diluents for reagent preparation and for titration media, and as antibody detecting media.

REFERENCES:
patent: 2770572 (1956-11-01), Eldon
patent: 2938892 (1960-05-01), Sheehan
Franz, Chem. Abs., vol. 77, 1972, Ab. No. 138309d.
Shrivastava, Chem. Ab. vol. 77, 1972, Ab. No. 71643n.
Westphal, Chem. Abs., vol. 79, 1973, Ab. No. 62698y.
Payne, Chem. Abs., vol. 80, 1974, Ab. No. 105502v.
Dunsford, Tech. in Blood Banking, Oliver & Boyd Pub., London, 1955, pp. 23-27.
Means, Chemical Modification of Proteins, Holden-Day, San Francisco, 1971, pp. 39-43, 145-148.
Goodfriend, Science, vol. 144, June 12, 1964, pp. 1344-1346.
Adler, The J. of Immunol., vol. 106, June, 1971, pp. 1684-1685.

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