Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-09-05
2006-09-05
Sullivan, Daniel M. (Department: 1636)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S024500, C514S04400A, C435S455000, C435S458000, C435S402000
Reexamination Certificate
active
07101995
ABSTRACT:
Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.
REFERENCES:
patent: 6180784 (2001-01-01), Wolff et al.
Oku et al. A novel non-viral gene transfer system, polycation liposomes. Adv Drug Deliv Rev. Nov. 19, 2001;52(3):209-18.
Morcos PA. Achieving efficient delivery of morpholino oligos in cultured cells. Genesis. Jul. 2001;30(3):94-102.
Caplen et al, “DSRNA-Mediated Gene Silencing in Cultured Drosophila Cells: a Tissure Culture Model for the Analysis of RNA Interference,” Gene; 2000, vol. 252, pp. 95-105.
Caplen et al, “Specific Inhibition of Gene Expression by Small Double-Stranded RNAS in Invertebrate and Vertebrate Systems,” PNAS; 2001, vol. 98, No. 17, 9742-9747.
Catalanotto et al, “Gene Silencing in Worms and Fungi,” Nature; 2000, vol. 404,245.
Clemens et al, “The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function,” Journal of Interferon and Cytokine Research; 1997, vol. 17, pp. 503-524.
Elbashir et al, “Duplexes of 21-Nucleotide RNAS Mediate RNA Interference in Cultured Mammalian Cells,” Nature; 2001, vol. 411, 494-498.
Elbashir et al, “RNA Interference is Mediated by 21- and 22-Nucleotide RNAS,” Genes and Development; 2001, vol. 15, pp. 188-200.
Fagard et al, “AG01, QDE-2, and RDE-1 are Related Proteins Required for Post-Transcriptional Gene Silencing in Plants, Quelling in Fungi, and RNA Interference in Animals,” PNAS; 2000, vol. 97, pp. 11650-11654.
Gao et al, “A Novel Cationic Liposome Reagent for Efficient Transfection of Mammalian Cells,” Biochemical and Biophysical Research Communications; 1991, vol. 179, No. 1, 280-285.
Hamilton et al, “A Species of Small Antisense RNA in Posttranscripitional Gene Silencing in Plants,” Science; 1999, vol. 286, 950-952.
Hammond et al, “An RNA-Directed Nuclease Mediates Post-Transcriptional Gene Silencing in Drosopila Cells,” Nature; 2000, vol. 404, 293-296.
Ketting et al, “NUT-7 of C. Elegans, Required for Transposon Silencing and RNA Interference, is a Homolog of Werner Syndrome Helicase and RNASED,” Cell; 1999, vol. 99, pp. 133-141.
Leventis et al, “Interactions of Mammalian Cells with Lipid Dispersions Containing Novel Metabolizable Catonic Amphilphiles,” Biochimica et Biophysica Acta.; 1990, vol. 1023, pp. 124-132.
Manche et al, “Interactions Between Double-Stranded RNA Regulators and the Protein Kinase DAI,” Molecular and Cellular Biology; 1992, pp. 5238-5248.
Minks et al, “Structural Requirements of Double-Stranded RNA for the Activation of 2', 5'-Oligo(A) Polymerase and Protein Kinase of Interferon-Treated Hela Cells,” The Journal of Biological Chemistry; 1979, vol. 254, pp. 10180-10183.
Parrish et al, “Functional Anatomy of a DSRNA Trigger: Differential Requirement for the Two Trigger Strands in RNA Interference,” Molecular Cell; 2000, vol. 6, pp. 1077-1087.
Player et al, “THE2-5A System: Modulation of Viral and Cellular Processes Through Acceleration of RNA Degradation,” Pharmacol. Ther.; 1998, vol. 78, pp. 55-113.
Reidhaar-Olson et al, “The Impact of Genomics Tools on Target Discovery,” Current Drug Discovery; 2001, pp. 20-24.
Sharp et al, “RNA Interference-2001,” Genes and Development; 2001, vol. 15, pp. 485-490.
Summerton et al, “Morpolino and Phosphorothioate Antisense Oligomers Compared in Cell-Free and in-Cell Systems,” Antisense and Nucleic Acid Drug Development; 1997, vol. 7, pp. 63-70.
Svoboda et al, “Selective Reduction of Dormant Maternal MRNAS in Mouse Oocytes By RNA Interference,” Development; 2000, vol. 127, pp. 4147-4156.
Tabara et al, “The RDE-1 Gene, RNA Intereference, and Transposon Silencing in C. Elegans,” Cell; 1999, vol. 99, pp. 123-132.
Tuschl et al, “Targeted MRNA Degradation by Double-Stranded RNA in vitro,” Genes and Development; 1999, vol. 13, pp. 3191-3197.
Yang et al, “Evidence That Processed Small DSRNAS May Mediate Sequence-Specific MRNA Degradation During RNAI in Drosopila Embryos,” Current Biology; 2000, vol. 10, pp. 1191-1200.
Zamore et al, “RNAI: Double-Stranded RNA Directs the ATP-Dependent Cleavage of MRNA at 21 to 23 Nucleotide Intervals,” Cell; 2000, vol. 101, pp. 25-33.
Hagstrom James E.
Herweijer Hans
Lewis David L.
Loomis Aaron G.
Monahan Sean D.
Ekena Kirk
Johnson Mark K.
Mirus Bio Corporation
Sullivan Daniel M.
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