Compositions and process for the treatment of cancer

Details Compositions and process for the treatment of cancer Compositions and process for the treatment of cancer

1983-01-12

1984-08-21

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

2603975, 424 9, 424148, 568 1, A61K 4300, A61K 4900, C01J 4100

Patent

active

044669526

ABSTRACT:
Novel estratriene and estratetraene compositions bearing a dicarbadodecaboranyl substituent at the 17-position have been prepared which possess high uterotropic and estrophilic activity useful in boron neutron capture destruction of cancerous cells.

REFERENCES:
patent: 4260736 (1981-04-01), Asano et al.
Hawthorne et al., J. Med. Chem., vol. 15, (1972), pp. 449-452.
Raynaud et al., Cancer Research, vol. 38, (1978), pp. 3044-3050.
Kahl and Wolff, Aug. 29, 1980, "The Synthesis and Properties of Some Boron-Containing Steroids for Use in Boron Neutron Cancer Therapy", presented at Second Chemical Congress of the North American Continent, Las Vegas, Nevada.
Sweet and Samant, "Boron Derivatives of Estradiol and Testosterone for .sup.10 B-Neutron Capture Therapy of Cancers of the Female and Male Reproductive Systems", Jun. 1982.
Sweet, Boron Estrogens: "Synthesis, Biochemical and Biological Testing of Estrone and Estradiol-178 3-carboranylmethyl Ethers", (Steroids 37, 223-238, (1981).
Hatanaka, "A Revised Boron-Neutron Capture Therapy for Malignant Brain Tumors", J. Neurol., 209, 81-94, (1975).
Brownell, Zamenhof, Murray, and Wellum, Chapt. 18, "Boron Neutron Capture Therapy", in Nuclear Medicine, (1977, Spencer, ed.).

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