Compositions and methods utilizing DNA polymerases

Details Compositions and methods utilizing DNA polymerases Compositions and methods utilizing DNA polymerases

2005-09-20

2005-09-20

Hutson, Richard (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S183000, C530S350000, C536S023200, C424S094500

Reexamination Certificate

active

06946273

ABSTRACT:
The invention features a novel isolated Family B DNA polymerase, aThermococcuspolymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′ to 5′ exonuclease activity and/or exhibit reduced discrimination against non-conventional nucleotides relative to the wild-type form of the polymerase.

REFERENCES:
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patent: WO 97/39150 (1997-10-01), None
patent: WO 99/06538 (1999-02-01), None
Dong et al., Mutational Studies of Human DNA Polymerase alpha, Journal of Biological Chemistry, vol. 268, No. 15, pp. 24163-24174, 1993.
Stryer, Biochemistry, Third Edition, 1988, W.H. Freeman and Co., New York, p. 72.
International Search Report of International Application No. PCT/US02/20562.
Gardner and Jack,Nucleic Acids Research,1999, vol., 27, No. 12 2545-2553.

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