Compositions and methods using direct MMP inhibitors for...

Details Compositions and methods using direct MMP inhibitors for... Compositions and methods using direct MMP inhibitors for...

2005-09-13

2005-09-13

Kim, Vickie (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Cosmetic, antiperspirant, dentifrice

C424S059000, C514S725000

Reexamination Certificate

active

06942870

ABSTRACT:
Compositions and methods are provided for ameliorating various effects of UVA and UVB radiation from the sun. The compositions include an ingredient that prevents photoaging from MED and subMED radiation, namely a direct acting MMP (matrix metalloproteinase) inhibitor. The compositions can include another, indirect MMP inhibitor, such as a retinoid, certain other compounds (such as N-acetylcysteine, 2-furildioxime, and vitamin C), tetracyclines, and if a retinoid is used then in addition optional compounds that inhibit the CYP-26 (chytochrome P-450) mediated metabolism of retinoids such as ketoconazole and other azole compounds. In the method, the composition is applied prior to exposure to the sun; for direct acting MMP inhibitors, application should be just prior to exposure, and if indirect inhibitors such as retinoids are used in addition, then application of the indirect inhibitor should be at least about seven hours prior to exposure. Compounds that prevent erythema (skin reddening, sunburn) do not necessarily protect against UV-mediated elevation of MMP levels and activity, and similarly compounds that prevent UV-mediated elevation of MMP levels and activity are not necessarily effective against UV-induced erythema.

REFERENCES:
patent: 4455368 (1984-06-01), Kojima
patent: 4654354 (1987-03-01), Shroot et al.
patent: 4877805 (1989-10-01), Kligman
patent: 4885282 (1989-12-01), Thornfeldt
patent: 5002760 (1991-03-01), Katzev
patent: 5260059 (1993-11-01), Acott et al.
patent: 5296500 (1994-03-01), Hillebrand
patent: 5364617 (1994-11-01), Bush
patent: 5459332 (1995-10-01), Carruthers
patent: 5609854 (1997-03-01), Guerrero
patent: 5612215 (1997-03-01), Draper
patent: 5614178 (1997-03-01), Bloom
patent: 5618522 (1997-04-01), Kaleta
patent: 5629365 (1997-05-01), Razavi
patent: 5710177 (1998-01-01), Sauermann
patent: 5780042 (1998-07-01), Gers-Barlag et al.
patent: 5824702 (1998-10-01), Wei
patent: 5837224 (1998-11-01), Voorhees et al.
patent: 5916910 (1999-06-01), Lai
patent: 6080393 (2000-06-01), Liu et al.
patent: 6153176 (2000-11-01), Kaleta et al.
patent: 2528420 (1983-12-01), None
patent: 82 10425 (1983-12-01), None
patent: WO 93/10755 (1993-06-01), None
patent: WO93/10755 (1993-06-01), None
patent: WO94/09756 (1994-05-01), None
patent: WO95/27485 (1995-10-01), None
patent: WO 96/23490 (1996-08-01), None
patent: WO 96/41614 (1996-12-01), None
Braunhut et al., Retinoids modulate endothelial cell . . . , Database CAPLUS, AN 1994:315797, abstract only, Journal of Blologic Chemistry, 1994, vol. 269(18), pp. 13472-13479.
Pan et al., Suppression of collagenase gene expression by all-trans and . . . , Database Caplus AN1995:512895, abstract only, Journal of Cellular Biochemistry, 1995, vol 57(4), pp. 575-589.
Tiberio et al., Retinoic acid- enhanced invasion . . . , Database CAPLUS, AN 1997:766891, abstract only, International Journal o Cancer, 1997, vol. 73(5), pp. 740-748.
Li et al., The Redox Active Components . . . , Experimental Eye Research, vol. 59/2, p. 179-190, Aug. 1994.
Daphna-Iken et al, Interleukin-1. beta. induces . . . , American J. of Phy., vol. 269/6 38-6, pp. F831-F837, 1995.
Nikolowski et al., In vivo testing of antiinflammatory . . . , adstract, Dermatol. Monatsschr. 1982, vol. 168/3, pp. 173-181.
Van Wauwe et al., Ketoconazole inhibitos the in vitro and in vivo . . . , abstract, J. Pharmacol. Exp. Ther., 1988, vol. 245/2, pp. 718-722.
Braunhut et al., Retinoids modulate endothelial cell . . . , abstract, J/Biol. Chem., 1994, col. 269/18, pp. 13472-13479.
Gary J. Fisher, et al., “Molecular Basis of Sun-Induced Premature Skin Aging Retinoid Antagonism”, Nature, GB, McMillian Jml, Ltd., London, Jan. 25, 1996, pp. 335-339.
Nikolowski, et al, “in Vivo Testing of Anti-inflamitory . . . ”, abstract, Dermatol, Montasschr, 1982, vol. 168/3, pp. 173-181.
Van Wauwe, et al, “Ketonconazole Inhibits the in-Vitro and in-Vivo . . . ”, abstract, J. Pharmacol, exp. Ther. 1998 vol. 245/2, pp. 718-722.
Braunhut, et al, “Retinoids Modulate, Endothelial Cell . . . ” abstract, J/Biol. Chem, 1994, col. 269/18, pp. 13472-13479.

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