Compositions and methods using apocynin compounds and nitric...

Details Compositions and methods using apocynin compounds and nitric... Compositions and methods using apocynin compounds and nitric...

2005-10-03

2011-11-29

Henley, III, Raymond (Department: 1629)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

C514S645000, C514S688000, C514S742000

Reexamination Certificate

active

08067464

ABSTRACT:
The invention describes novel compositions comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The invention also provides novel kits comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor compound, and, optionally, at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating gastrointestinal disorders; (h) treating inflammatory disorders; and (j) treating respiratory disorders; and (k) treating peripheral vascular diseases. The apocynin compound may preferably be apocynin. The nitric oxide donor compound may preferably be isosorbide dinitrate and/or isosorbide mononitrate.

REFERENCES:
patent: 4780401 (1988-10-01), Heusser et al.
patent: 4845079 (1989-07-01), Luly et al.
patent: 4868179 (1989-09-01), Cohn
patent: 4885292 (1989-12-01), Ryono et al.
patent: 4894437 (1990-01-01), TenBrink
patent: 4980283 (1990-12-01), Huang et al.
patent: 5034512 (1991-07-01), Hudspeth et al.
patent: 5036053 (1991-07-01), Himmelsbach et al.
patent: 5036054 (1991-07-01), Kaltenbronn et al.
patent: 5055466 (1991-10-01), Weller, III et al.
patent: 5063207 (1991-11-01), Doherty et al.
patent: 5063208 (1991-11-01), Rosenberg et al.
patent: 5064965 (1991-11-01), Ocain et al.
patent: 5066643 (1991-11-01), Abeles et al.
patent: 5071837 (1991-12-01), Doherty et al.
patent: 5075451 (1991-12-01), Ocain et al.
patent: 5089471 (1992-02-01), Hanson et al.
patent: 5095006 (1992-03-01), Bender et al.
patent: 5095119 (1992-03-01), Ocain et al.
patent: 5098924 (1992-03-01), Poss
patent: 5104869 (1992-04-01), Albright et al.
patent: 5106835 (1992-04-01), Albright et al.
patent: 5114937 (1992-05-01), Hamby et al.
patent: 5116835 (1992-05-01), Ruger et al.
patent: 5262165 (1993-11-01), Govil et al.
patent: 5284872 (1994-02-01), Sandrock et al.
patent: 5344991 (1994-09-01), Reitz et al.
patent: 5380738 (1995-01-01), Norman et al.
patent: 5380758 (1995-01-01), Stamler et al.
patent: 5393790 (1995-02-01), Reitz et al.
patent: 5409944 (1995-04-01), Black et al.
patent: 5428061 (1995-06-01), Sandrock et al.
patent: 5434178 (1995-07-01), Talley et al.
patent: 5436265 (1995-07-01), Black et al.
patent: 5466823 (1995-11-01), Talley et al.
patent: 5474995 (1995-12-01), Ducharme et al.
patent: 5510368 (1996-04-01), Lau et al.
patent: 5536752 (1996-07-01), Ducharme et al.
patent: 5550142 (1996-08-01), Ducharme et al.
patent: 5552422 (1996-09-01), Gauthier et al.
patent: 5604253 (1997-02-01), Lau et al.
patent: 5604260 (1997-02-01), Guay et al.
patent: 5639780 (1997-06-01), Lau et al.
patent: 5650447 (1997-07-01), Keefer et al.
patent: 5661129 (1997-08-01), Feelisch et al.
patent: 5703073 (1997-12-01), Garvey et al.
patent: 5807847 (1998-09-01), Thatcher et al.
patent: 5859053 (1999-01-01), Lesur et al.
patent: 5874437 (1999-02-01), Garvey et al.
patent: 5883122 (1999-03-01), Thatcher et al.
patent: 5910316 (1999-06-01), Keefer et al.
patent: 5932598 (1999-08-01), Talley et al.
patent: 5948433 (1999-09-01), Burton et al.
patent: 5958926 (1999-09-01), Garvey et al.
patent: 5994294 (1999-11-01), Garvey et al.
patent: 6010715 (2000-01-01), Wick et al.
patent: 6057347 (2000-05-01), Garvey et al.
patent: 6071531 (2000-06-01), Jona et al.
patent: 6090851 (2000-07-01), Dodd et al.
patent: 6133272 (2000-10-01), Garvey et al.
patent: 6172060 (2001-01-01), Garvey et al.
patent: 6172068 (2001-01-01), Garvey et al.
patent: 6177428 (2001-01-01), Garvey et al.
patent: 6197782 (2001-03-01), Garvey et al.
patent: 6211179 (2001-04-01), Garvey et al.
patent: 6221881 (2001-04-01), Garvey et al.
patent: 6232321 (2001-05-01), Garvey et al.
patent: 6232336 (2001-05-01), Hrabie et al.
patent: 6297260 (2001-10-01), Bandarage et al.
patent: 6316457 (2001-11-01), Garvey et al.
patent: 6331542 (2001-12-01), Carr et al.
patent: 6633272 (2003-10-01), Kumagawa et al.
patent: 2005/0059655 (2005-03-01), Garvey et al.
patent: WO-9309806 (1993-05-01), None
patent: WO-9403387 (1994-02-01), None
patent: WO-9403421 (1994-02-01), None
patent: WO-9404484 (1994-03-01), None
patent: WO-9412463 (1994-06-01), None
patent: WO-9415723 (1994-07-01), None
patent: WO-9420480 (1994-09-01), None
patent: WO-9426731 (1994-11-01), None
patent: WO-9427980 (1994-12-01), None
patent: WO-9500501 (1995-01-01), None
patent: WO-9509831 (1995-04-01), None
patent: WO-9515316 (1995-06-01), None
patent: WO-9519952 (1995-07-01), None
patent: WO-9530641 (1995-11-01), None
patent: WO-9603387 (1996-02-01), None
patent: WO-9603388 (1996-02-01), None
patent: WO-9606840 (1996-03-01), None
patent: WO-9621667 (1996-07-01), None
patent: WO-9631509 (1996-10-01), None
patent: WO-9636623 (1996-11-01), None
patent: WO-9714691 (1997-04-01), None
patent: WO-9716435 (1997-05-01), None
patent: WO-9719679 (1997-06-01), None
patent: WO-9727749 (1997-08-01), None
patent: WO-9746521 (1997-12-01), None
patent: WO-9819672 (1998-05-01), None
patent: WO-9821193 (1998-05-01), None
patent: WO-0028988 (2000-05-01), None
patent: WO-0050037 (2000-08-01), None
patent: WO-0051988 (2000-09-01), None
patent: WO-0054756 (2000-09-01), None
patent: WO-0061537 (2000-10-01), None
patent: WO-0061541 (2000-10-01), None
patent: WO-0061604 (2000-10-01), None
patent: WO-0072838 (2000-12-01), None
patent: WO-0100563 (2001-01-01), None
patent: WO-0104082 (2001-01-01), None
patent: WO-0110814 (2001-02-01), None
patent: WO-0112584 (2001-02-01), None
patent: WO-0145703 (2001-06-01), None
patent: WO-0187343 (2001-11-01), None
patent: WO-0211707 (2002-02-01), None
patent: WO-0230866 (2002-04-01), None
patent: WO-03013432 (2003-02-01), None
patent: WO-03017996 (2003-03-01), None
PCT International Search Report for Application No. PCT/US05/35715 dated Aug. 10, 2006.
Brideau, et al., Inflamm Res., 45: 68-74 (1996).
Drug Facts and Comparisons, Inc., St. Louis, MO (1993).
Goodman and Gilman, The Pharmacological Basis of Therapeutics (9th Edition), McGraw-Hill, pp. 901-915 (1995).
Goodman and Gilman, The Pharmacological Basis of Therapeutics (9th Edition), McGraw-Hill, pp. 617-657 (1995).
Greene and Wuts, Protective Groups in Organic Synthesis, Third Edition, John Wiley & Sons, New York (1999).
Ignarro, et al., Proc. Natl. Acad. Sci. USA, 84:9265-9269 (1987).
Merck Index on CD-ROM, 13th Edition.
Oae, et al., Org. Prep. Proc. Int., 15(3):165-198 (1983).
Palmer, et al., Nature 327:524-526 (1987).
The Physician's Desk Reference (49th Ed.), Medical Economics Company, Inc., Oradell, N.J. (1995).

Affiliated with

Also associated with

Rating

Compositions and methods using apocynin compounds and nitric... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods using apocynin compounds and nitric..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods using apocynin compounds and nitric... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4287094