Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-08-02
2010-06-01
Haq, Shafiqul (Department: 1641)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C435S007240, C435S069100, C435S070210, C435S452000, C435S332000, C435S337000, C435S975000, C436S506000, C436S512000, C436S548000, C530S387300, C530S388250, C530S866000
Reexamination Certificate
active
07728115
ABSTRACT:
The invention includes compositions, kits and methods comprising a monoclonal antibody which shares key functional properties with the polyclonal antibodies which participate in the pathogenesis of heparin induced thrombocytopenia/thrombosis (HIT/HITT) in a mammal. The monoclonal antibody of the invention preferentially binds with a PF4/heparin complex relative to the binding of the antibody with PF4 or heparin alone. The monoclonal antibody of the invention also binds specifically with PF4 in a complex with other glycosaminoglycans besides heparin, and also activates platelets. The monoclonal antibody of the invention is useful in methods for diagnosing and treating HIT/HITT in a mammal. A humanized version of the monoclonal antibody of the invention is also included, along with a process for humanizing the monoclonal antibody of the invention.
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Arepally Gowthami M.
Kamei Keiko
Kamei Shintaro
Kisiel Walter
Grun James L
Haq Shafiqul
Mueting Raasch & Gebhardt, P.A.
STC. UNM
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