Compositions and methods useful for producing analgesia

Details Compositions and methods useful for producing analgesia Compositions and methods useful for producing analgesia

1983-07-14

1985-01-15

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

A61K 31165

Patent

active

044938489

ABSTRACT:
A composition, useful for producing analgesia in humans or lower animals, comprising a safe and effective amount of: an N-[(substituted phenyl)methyl]-cis-monounsaturated alkenamide pharmaceutically-acceptable salts thereof, or mixtures thereof; and a pharmaceutically-acceptable carrier. Preferably, these alkenamides are N-vanillyl-cis-monounsaturated alkenamides. Methods of treatment, comprising administering a safe and effective amount of these alkenamides, pharmaceutically-acceptable salts thereof, or mixtures thereof, include methods of parenteral, oral, and topical administration.

REFERENCES:
patent: 3268582 (1966-08-01), Zeile et al.
patent: 4238508 (1980-12-01), Nelson
patent: 4313958 (1982-02-01), LeHann
patent: 4401663 (1983-08-01), Buckwalter et al.
Ferris et al., "New Approach to Insecticidal Paints", Aust. Commonwealth Dept. Supply Det. Stand. Lab., Tech. Note No. 89, (1966), (Chem. Abs. 67:22919s).
Kiernan, "A Study of Chemically Induced Acute Inflammation in the Skin of the Rat", Quart. J. Exp. Physiol., vol. 62, (1977), pp. 151-161.
Jansco et al., "Direct Evidence for Neurogenic Inflammation and its Prevention by Denervation and by Pretreatment with Capsaicin," Br. J. Pharm. Chemother., vol. 3, (1967), pp. 138-151.
Jones et al., "The Relation Between Chemical Constitution and Pungency in Acid Amides," J. Chem. Soc., vol. 27, (1925), pp. 2588-2598.
Newman, "Natural and Synthetic Pepper-Flavored Substances," Chem. Prod., (Mar. 1954), pp. 102-106.
Szolesanyi et al., "Sensory Effects of Capsaicin Congeners," Arzneim.-Forsch., vol. 25, 26, (1975), pp. 1871-1881, 33-37.
Hegyes et al., "Synthesis of Homovanillic Acid Derivatives of Capsaicin-Like Effect," Acta. Phys. Chem., vol. 20, (1974), pp. 115-120.
Michalski et al., "Synthesis and Local Anesthetic Properties of N-Substituted 3,4-Dimethoxyphenethylamine Derivatives," Diss. Pharm. Pharmacol., vol. 24, (1972), pp. 17-25, (Chem. Abs. 77:19271a).
T. Szeki, "Contributions Towards Understanding the Relation Between the Chemical Constitution and the Sharp Taste of Acylamines," Arch. Pharm., vol. 268, (1930), pp. 151-157.
Ott et al., Liebigs Ann., vol. 425, (1921), pp. 314-337.

Affiliated with

Also associated with

Rating

Compositions and methods useful for producing analgesia does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods useful for producing analgesia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods useful for producing analgesia will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1481101