Compositions and methods useful for inhibiting cell death and fo

Details Compositions and methods useful for inhibiting cell death and fo Compositions and methods useful for inhibiting cell death and fo

1995-04-24

1998-07-14

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

436829, A61K 9127

Patent

active

057800529

ABSTRACT:
The invention relates to methods of salvaging a target cell from cell death, comprising contacting a target cell having a disrupted cell membrane with a specific affinity reagent-liposome conjugate in an amount effective and for a time sufficient to allow the conjugate to prevent cell death due to membrane disruption; and determining the viability of the target cell. Methods of delivering a selected agent into a damaged target cell for diagnosis and therapy are also disclosed.

REFERENCES:
patent: 4957735 (1990-09-01), Huang
patent: 5230900 (1993-07-01), Hakamori
Machy et al., "Gene transfer from targeted liposomes to specific lymphoid cells by electroporation," Proc. Natl. Acad. Sci. USA 85:8027-8031 (1988).
Mueller et al., "Liposome Concentration in Canine Ischemic Myocardium and Depolarized Myocardial Cells," Circulation Research 49:405-415 (1981).
Khaw et al., "Monoclonal Antibody to Cardiac Myosin: Imaging of Experimental Myocardial Infarction," Hybridoma 3:11-23 (1984).
Torchilin et al., "Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium," The FASEB Journal 6:2716-2719 (1992).
Torchilin et al., "Preservation of antimyosin activity after covalent coupling to liposomes," Biochemical & Biophysical Research Communications 89:1114 (1979).

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