Compositions and methods to stack multiple nucleotide...

Details Compositions and methods to stack multiple nucleotide... Compositions and methods to stack multiple nucleotide...

2008-11-06

2010-10-26

Mehta, Ashwin (Department: 1638)

Multicellular living organisms and unmodified parts thereof and

Method of introducing a polynucleotide molecule into or...

Reexamination Certificate

active

07820880

ABSTRACT:
Methods and compositions for the stacking of multiple nucleotide sequences at precise locations in the genome of a plant or plant cell are provided. Specifically, transfer cassettes comprising nucleotide sequences of interest flanked by non-identical recombination sites are introduced into a plant comprising a target site. The target site contains at least a set of non-identical recombination sites corresponding to those on the transfer cassette. Exchange of the nucleotide sequences flanked by the recombination sites is effected by a recombinase. The transfer cassettes and target sites are designed so as to allow for the stacking or ordering of nucleotide sequences at precise locations in the plant genome.

REFERENCES:
patent: 5013659 (1991-05-01), Bedbrook et al.
patent: 5565350 (1996-10-01), Kmiec
patent: 5677177 (1997-10-01), Wahl et al.
patent: 5723765 (1998-03-01), Oliver et al.
patent: 5744336 (1998-04-01), Hodges
patent: 5756325 (1998-05-01), Kmiec
patent: 5928914 (1999-07-01), Leboulch et al.
patent: 6010884 (2000-01-01), Griffiths et al.
patent: 6171861 (2001-01-01), Hartley et al.
patent: 6187994 (2001-02-01), Baszczynski et al.
patent: 6262341 (2001-07-01), Baszczynski et al.
patent: 6300545 (2001-10-01), Baszczynski et al.
patent: 6331661 (2001-12-01), Baszczynski et al.
patent: 6455315 (2002-09-01), Baszczynski et al.
patent: 6458594 (2002-10-01), Baszczynski et al.
patent: 6541231 (2003-04-01), Baszczynski et al.
patent: 6552248 (2003-04-01), Baszczynski et al.
patent: 6573425 (2003-06-01), Baszczynski et al.
patent: 6624297 (2003-09-01), Baszczynski et al.
patent: 6664108 (2003-12-01), Baszczynski et al.
patent: 6774279 (2004-08-01), Dymecki
patent: 7102055 (2006-09-01), Baszczynski et al.
patent: 7179599 (2007-02-01), Baszczynski et al.
patent: 7361508 (2008-04-01), Baszczynski et al.
patent: 7405079 (2008-07-01), Baszczynski et al.
patent: 2003/0119166 (2003-06-01), Baszczynski et al.
patent: 2003/0226160 (2003-12-01), Baszczynski et al.
patent: 2004/0083500 (2004-04-01), Baszczynski et al.
patent: 2006/0195937 (2006-08-01), Baszczynski et al.
patent: 2006/0253939 (2006-11-01), Baszczynski et al.
patent: 2 174 995 (1986-11-01), None
patent: WO 92/15694 (1992-09-01), None
patent: WO 92/17484 (1992-10-01), None
patent: WO 93/01283 (1993-01-01), None
patent: WO 93/17116 (1993-09-01), None
patent: WO 94/17176 (1994-08-01), None
patent: WO 95/00555 (1995-01-01), None
patent: WO 95/15388 (1995-06-01), None
patent: WO 95/15972 (1995-06-01), None
patent: WO 96/04393 (1996-02-01), None
patent: WO 97/04103 (1997-02-01), None
patent: WO 97/09436 (1997-03-01), None
patent: WO 97/09439 (1997-03-01), None
patent: WO 97/13401 (1997-04-01), None
patent: WO 97/37012 (1997-10-01), None
patent: WO 97/47758 (1997-12-01), None
patent: WO 97/48714 (1997-12-01), None
patent: WO 98/54330 (1998-12-01), None
patent: WO 99/07865 (1999-02-01), None
patent: WO 99/23202 (1999-05-01), None
patent: WO 99/25853 (1999-05-01), None
patent: WO 99/55851 (1999-11-01), None
Merriam Webster Online Dictionary, 2009.
U.S. Appl. No. 12/061,314, filed Apr. 2, 2008, Baszczynski et al.
U.S. Appl. No. 12/184,564, filed Apr. 1, 2008, Basczcynski et al.
Abremski, K.E., and R. Hoess, “Evidence for a Second Conserved Arginine Residue in the Integrase Family of Recombination Proteins,”Protein Engineering, 1992, pp. 87-91, vol. 5(1), Oxford University Press.
Albert et al., Site-Specific Integration of DNA into Wild-Type and Mutant Lox Sites Placed in the Plant Genome,The Plant Journal.(Jan. 18, 1995) pp. 649-659 vol. 7, No. 4, Plant Gene Expression Center, USDA/ARS-UC Berkeley, Albany, CA.
Araki et al,. “Targeted Integration of DNA Using Mutant Lox Sites in Embryonic Stem Cells,”Nucleic Acids Research(1997) pp. 868-872 vol. 25(4), Oxford University Press.
Bethke et al., “Segmental Genomic Replacement by Crer-Mediated Recombination: Genotoxic Stress Activation of the P53 Promoter in Single-Copy Transformants,”Nucleic Acids Research(1997) pp. 2828-2834 vol. 25(14) National Institutes of Health, National Institute of Diabetes, Digestive and Kidney Disease, Bethesda, MD.
Boulton, M.I., et al., “Specificity ofAgrobacterium-Mediated Delivery of Maize Streak Virus DNA to Members of the Gramineae”,Plant Molecular Biology, 1989, pp. 31-40, vol. 12.
Bravo-Angel, A., et al., “The Omega Sequence of VirD2 is Important but not Essential for Efficient Transfer of T-DNA byAgrobacterium tumefaciens,” 1998, pp. 57-63, vol. II(I).
Brisson, N., et al., “Expression of a Bacterial Gene in Plants by Using a Viral Vector,”Letters to Nature, 1984, pp. 511-514, vol. 310.
Campbell et al., Codon Usage in Higher Plants, Green Algae, and Cyanobacteria, Plant Physiol., 1990, pp. 1-11, vol. 92, Houghton, Michigan.
Chiu, W., et al., “Engineered GFP as a Vital Reporter in Plants,”Current Biol., 1996, pp. 325-330, vol. 6(3).
Czako et al. (1997) “Negative Selection Markers for Plants”, Technology Transfer of Plant Biotechnology, Chapter 6, CRC Press, Inc., Edited by Peter M. Gresshoff, Plant Molecular Genetics, Institute of Agriculture, Center for Legume Research, The University of Tennessee, Knoxville, Tennessee, 67-93, (1997), vol. 6.
Dale et al., Gene Transfer with Susequent Removal of the Selection Gene from the Host Genome, Proc. Natl. Acad. Sci. USA (Dec. 1991) pp. 10558-10562, vol. 88: Plant Gene Expression Center, USDOA/Agr. Res. Svs., Albany, CA and Dept. Plant Pathology, Univ. of Calif, Berkeley, California.
Dale, et al., “Intra- and Intermolecular Site-Specific Recombination in Plant Cells Mediated by Bacteriophage P1 Recombinase”,Gene, 1990, 91:79-85.
Dasgupta et al. (1991) “Rice Tungro Bacilliform Virus DNA Independently Infects Rice AfterAgrobacterium-Mediated Transfer”,Journal of General Virology72:1215-1221.
Dildine, S.L., et al., “A Chimeric Ty3/Moloney Murine Leukemia Virus Integrase Protein is Active In Vivo,”J. of Virology, 1998, pp. 4297-4307, vol. 72(5).
Esposito, M.S., et al., “Recombinators, Recominases and Recombination Genes of Yeasts,”Curr. Genetics, 1994, pp. 1-11, vol. 25.
Feil et al., “Regulation of Cre Recombinase Activity by Mutated Estrogen Receptor Ligand-Binding Domaiins,”Biochem. and BioPhy. Res. Comm(1997).pp. 172-757, vol. 237 Institute de Genetique et de Biologie Moleculaire et Cellulaire, College de France, Strasbourg, France.
Fry, et al., “Transformation ofBrassica napuswithAbrobacterium tumefaciensBased Vectors,”Plant Cell Rep., 1987, pp. 321-325, vol. 6.
Golic et al., FLP-Mediated DNA Mobilization to Specific Target sites inDrosophiliaChromosomes,Nucleic Acids Research(1997) pp. 3665-3671 vol. 25(18) Dept. of Biol., Univ. of Utal, Salt Lake City, UT, Inst. of Path., Case Western Res. Univ., Cleveland, OH, Howard Hughes Med. Inst., Univ. of Chicago, Chicago, IL.
Grimsley et al. (1988) “Meristematic Tissues of Maize Plants are Most Susceptible to Agroinfection with Maize Streak Virus”,Bio/Technology6:185-189.
Hayes, et al., “Agroinfection ofNicotianaspp. With Cloned DNA of Tomato Golden Mosaic Virus,”J. Gen. Virol., 1988, pp. 1487-1496, vol. 69, SGM.
Karreman et al. (1996) “On the Use of Double FLP Recognition Targets (FRTs) in the LTR of Retroviruses for the Construction of High Producer Cell Lines”,Nucleic Acids Research24(9):1616-1624.
Kilby et al., FLP Recombinase in Transgenic Plants: Constitutive Activity in Stably Transformed Tobacco and Generation of Marked Cell Clones in Arabidopsis,The Plant Journal(1995) pp. 637-652 vol. 8(5) Institute of Biotech., Univ. of Cambridge, Cambridge, UK.
Kmiec et al., “Genetic Manipulation in Mammalian Cells Using an RNA/DNA Chimeric Oligonucleotide”,Advanced Drug Deliveries Review, 1995, pp. 333-340, vol. 17.
Lewin, 1983,Gene, p. 677.
Lloyd, A.M., and R.W. Davis, “Functional Expression of the Yeast FLP/FRT Site-Specific Recombination System inNicotiana tabacum,” Mol. Gen. Genet., 1994, pp. 653-657, vol. 24

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