Compositions and methods to regulate calmodulin gene expression,

Details Compositions and methods to regulate calmodulin gene expression, Compositions and methods to regulate calmodulin gene expression,

1996-11-08

1999-11-09

Campell, Bruce R.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 911, 4353201, 435377, 435455, 424450, 514 44, 536 245, 536 231, 536 233, 536 2331, 536 2333, C12N 510

Patent

active

059812796

ABSTRACT:
Constructs encoding calmodulin antisense molecules are disclosed. These constructs may be used to advantage to inhibit proliferation of malignant cells. The invention further comprises monoclonal antibody studded liposomes to facilitate cell-type specific delivery of the antisense calmodulin constructs. To enhance cell-type specific expression of calmodulin antisense sequences, cell-type specific promoters are employed to drive expression of the antisense molecules in targeted tissues.

REFERENCES:
Hait, W., et al., (1988), Cancer Investigation 6(5): 499-511.
Rasmussen, C., et al., (1989), The EMBO Journal 8: 73-82.
Lu, K.P., et al., (1993), Journal Cell Biology 121: 621-630.
Nojima, H., (1989), J. Mol. Biol. 208: 269-282.
Takeda, T., et al., (1987), Proc. Natl. Acad. Sci. USA 84: 3580-3584.
Liu, T., et al., (1992), Mol. Biol. of the Cell. 3: 1403-1413.
Colomer, J., et al., (1994), J. of Cell Physiol. 159: 542-550.
Christenson, M., et al., (1993), J. of Cell Physiol. 154: 343-349.
Bai, G., et al., (1992), Biochem Biophys. Acta 1130: 189-196.
Hait, W., et al., (1994), Anticancer Res. 14: 1711-1722.
Zhou, L.W., et al. (1985), Journ. Neurochem. 44: 1657-1662.
Cimino, M., et al. (1990), Dev. Brain. Res. 54: 43-49.
Roberts-Lewis, J.M. et al., (1990) SYNAPSE 5: 247-254.
Bai, G., et al., (1991), J. of Cell Physol. 149: 414-421.
Zhang, S.P., et al., (1993), Neuroscience 55: 571-582.
Natsukari, et al., (1995) Neurochem Int. 26: 465-476.
Davidkova, G., et al., (1996), Neuroscience, 75: 1003-1019.
Zhang, S.P. (1994), Soc. Neurosci. 20: 2316.
Solomon et al. (Clinical Res. vol. 41, 4, 800A, 1993).
E. Uhlmann et al. Chem. Rev. 90(4) 543-84, '90.
J. Milligan et al. J. Med. Chem. 36(14) 1923-37, '93.
C. Stein et al. Science 261: 1004-12, '93.
R. Stull et al. Pharm. Res. 12(4) 465-83, '95.
W. James Antivir. Chem. & Chemother. 2(4) 191-214, '91.
S. Orkin et al. NIH Report on Gene Therapy, '95.
T. Friedman et al. Scientific Amer. pp. 96-101, Jun. '97.
G. Davidkova et al. FASEB J. 9(3), p. A382 (Abstract), Mar. 1995.
R. Hinrichsen et al. P.N.A.S. 89: 8601-5, '92.
S. Solomon et al. B.B.R.C. 210(3) 9210-30, May 1995.
A. Thierry et al. Nucl. Acids Res. 20(21) 5691-98, '92.
E. Wagner et al. P.N.A.S. 87: 3410-4, '90.

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