Compositions and methods to prevent toxicity induced by nonstero

Details Compositions and methods to prevent toxicity induced by nonstero Compositions and methods to prevent toxicity induced by nonstero

1997-09-16

2000-05-02

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514374, 514393, 514411, 514412, 514416, 514448, 514539, 514611, 514681, 514727, 546121, 548126, 548235, 548432, 548444, 548472, 548491, 548539, 549 72, 560 36, 564112, 568 30, 568 42, A61K 3112, C07C20700, C07C20702, C07C20704

Patent

active

060573473

ABSTRACT:
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.

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