Compositions and methods to prevent toxicity induced by nonstero

Details Compositions and methods to prevent toxicity induced by nonstero Compositions and methods to prevent toxicity induced by nonstero

1999-01-22

2000-07-04

McKane, Joseph

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

514300, 514359, 514421, 5142265, 514418, 546113, 548259, 5483031, 548453, 548486, 544 48, 544 49, A61K 908, A61K 3141, C07D24916

Patent

active

06083515&

ABSTRACT:
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.

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