Compositions and methods to prevent toxicity induced by nonstero

Details Compositions and methods to prevent toxicity induced by nonstero Compositions and methods to prevent toxicity induced by nonstero

1999-01-22

2000-03-28

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514 19, 514162, 514165, 514166, 514413, 514546, 514567, A61K 31192, A61K 31407, A61K 31603, A61K 31606, A61K 3160

Patent

active

060432330

ABSTRACT:
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.

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