Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-10-13
1997-12-30
Grumbling, Matthew V.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544 48, 544 49, 544238, 544244, 544333, 544405, 544406, 544410, 544255, 5442622, 5443561, 560142, 560143, 548125, 548306, 514247, 514252, 514255, 514256, 514340, 514357, 514355, 514359, 514361, 514356, 514369, 514372, 514374, 514367, 514373, 514379, 514385, 514427, 514396, 514406, 514387, A61K 3154, A61K 3150, A61K 31505, A61K 3140, A61K 3144
Patent
active
057030731
ABSTRACT:
Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.
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Garvey David S.
Letts L. Gordon
Renfroe H. Burt
Tam Sang William
Grumbling Matthew V.
Herron Charles J.
NitroMed Inc.
Olstein Elliot M.
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