Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-02-13
2007-02-13
Siew, Jeffrey (Department: 1642)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023500, C536S024330, C536S024500, C435S091100, C435S091200, C435S094000
Reexamination Certificate
active
10048046
ABSTRACT:
An isolated nucleic acid sequence of a mitotic checkpoint gene, chfr, encodes a Chfr protein having a Forkhead-associated domain and a Ring Finger. This protein is required for regulation of the transition of cells from prophase to metaphase during mitosis. The chfr nucleic acid and Chfr polypeptide are useful in diagnosing tumorigenic cells and in screening for drugs which can inhibit the activity of Chfr in a cancer cell, thereby rendering the cell more sensitive to additional anti-tumor therapies.
REFERENCES:
patent: 5324630 (1994-06-01), LeFebvre et al.
patent: 5840708 (1998-11-01), Weiss
patent: 1074617 (2001-02-01), None
patent: WO99/11795 (1999-03-01), None
patent: WO00/21991 (2000-04-01), None
Bowie et al (Science, 1990, 257 : 1306-1310).
Burgess et al, (Journal of Cell Biology, 1990, 11: 2129-2138).
Lazar et al. Molecular and Cell Biology, 1988, 8: 1247-1252.
Tao. et al. The Journal of Immunology, 1989, 143(8): 2595-2601.
Gillies et al. Human Antibodies and Hybridomas , 1990, 1(1): 47-54.
Tockman et al (Cancer Res., 1992, 52:2711s-2718s).
Branch, AD, 1998, TIBS 23: 45-50.
Gura (Science, 1995, 270:575-577).
Miller (1995, FASEB J., vol. 9, pp. 190-199).
Deonarain (1998, Expert Opin. Ther. Pat., vol. 8, pp. 53-69).
Verma (Sep. 1997, Nature, vol. 389, pp. 239-242).
Crystal (1995, Science, vol. 270, p. 404-410).
MPSRCH search report, 2004, us-10-048-046-1.oligo.rng, pp. 18-19.
Boehringer Mannheim Biochemicals, 1994 Catalog, p. 93.
Sambrook et al, 1989, Molecular cloning, a Laboratory manual, 2nd ed, Cold spring Harbor Laboratory Press, Cold Spring Harbor, p. 10.6-10.7.
Sambrook et al, 1989, 2nd ed, Molecular cloning, A laboratory manual, Cold Spring Harbor laboratory Press, Cold Hpring Harbor, p. 10.13.
JP06303997-A, 1994, GenBank Accession No:AAQ75652 and MPSRCH search report, 2005, us-10-048-046-1.oligo.rng, p. 2.
US 5,610054-A, GenBank Accession No. I57653, and MPSRCH search report, 2005, us-10-048-046-1.copy 81-399.oligo.rge, p. 6.
Gold, DP et al, 1993, GenBank Accession No. S86452 and MPSRCH search report, 2005, us-10-048-046-1.copy 997-1128.oligo.rge, pp. 3-4.
George JF et al, 1992, GenBank Accession No. S81367, and MPSRCH search report, 2005, us-10-048-046-1.copy 1516-2013.oligo.rge, pp. 1, 4-5.
Drexler et al (Leukemia and Lymphoma, 1993, 9:1-25).
Embleton et al (Immunol Ser, 1984, 23:181-207).
Hsu (in Tissue Culture Methods and Applications, Kruse and Patterson, Eds, 1973, Academic Press, NY, see abstract, p. 764.
G. Zhu et al, “The Fork Head Transcription Factor Hcm1p Participates in the Regulation of SPC110, Which Encodes the Calmodulin-Binding Protein in the Yeast Spindle Pole Body”, Biochimica et Biophysica Acta, 1448(2):236-244 (Dec. 1998).
B. Ouyang et al, “Human Bub1: a Putative Spindle Checkpoint Kinase Closely Linked to Cell Proliferation”, Cell Growth & Differentiation, 9(10):877-885 (Oct. 1998).
K. Hardwick, “The Spindle Checkpoint”, Trends in Genetics, 14(1) 1-4 (Jan. 1998).
D. Cahill et al, “Mutations of Mitotic Checkpoint Genes in Human Cancers”, Nature, 392:300-303 (Mar. 1998).
D. Scolnick et al, “Chfr Defines a Mitotic Stress Checkpoint that Delays Entry into Metaphase”, Nature, 406(6794):430-435 (Jul. 2000).
D. Scolnick et al, “CHFR Prevents Chromosomal Condensation in Response to a Defective Spindle”, Proceedings of the American Association for Cancer Research, 40:215, Abstract No. 1422 (Mar. 1999).
M. Murone et al, “The Fission yeast dma1 Gene is a Component of the Spindle Assembly Checkpoint, Required to Prevent Septum Formation and Premature Exit from Mitosis if Spindle Function is Compromised”, EMBO J., 15(23):6605-6616 (Dec. 1996).
T. Isogai et al, “NEDO Human cDNA Sequencing Project”, Database GenBank, Accession No. AK001658, (Feb. 16, 2000).
S. Elledge et al, “Mitotic Arrest: Mad2 Prevents Sleepy from Waking up the APC”, Science, 279:99-100 (Feb. 1998).
A. Amon, “The Spindle Checkpoint”, Current Opinion in Genetics & Development, 9:69-75 (1999).
L. Muhua et al, “A Cyotkinesis Checkpoint Requiring the Yeast Homologue of an APC-Binding Protein”, Nature, 393:487-491 (Jun. 1998).
J. McIntosh et al, “Mitosis”, Science, 246:622-628 (Nov. 1989).
M. Jordan et al, “Microtubules and Actin Filaments: Dynamic Targets for Cancer Chemotherapy”, Current Opinion in Cell Biology, 10:123-130 (1998).
L. Hartwell et al, “Cell Cycle Control and Cancer”, Science, 266 1821 1828 (Dec. 1994).
C. Lengauer et al, Genetic Instability in Colorectal Cancers, Nature, 386:623-627 (Apr. 1997).
C. Lengauer et al, “Genetic Instabilities in Human Cancers”, Nature, 396:643-649 (Dec. 1998).
Y. Li et al, “Identification of a Human Mitotic Checkpoint Gene: hsMAD2”, Science, 274:246-248 (Oct. 1996).
K. Yamaguchi et al, “Mutation Analysis of hBUB1 in Aneuploid HNSCC and Lung Cancer Cell Lines”, Cancer Letters, 139:183-187 (1999).
D-Y. Jin et al., “Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1”, Cell, 93:81-91 (Apr. 1998).
H. Zou et al, “Identification of a Vertebrate Sister-Chromatid Separation Inhibitor Involved in Transformation and Tumorigenesis”, Science, 285:418-422 (Jul. 1999).
D. Cahill et al, “Characterization of MAD2B and Other Mitotic Spindle Checkpoint Genes”, Genomics, 58:181-187 (1999).
Halazonetis, T.D., “Constitutively active DNA damage checkpoint pathways as the driving force for the high frequency of p53 mutations in human cancer”,DNA Repair(Amst). Aug.-Sep. 2004 3(8-9):1057-1062.
Huyen et al., “Structural differences in the DNA binding domains of human p53 and itsC. elegansortholog Cep-1”,Structure(Camb). Jul. 2004 12(7):1237-1243.
Mariatos et al., “Inactivating mutations targeting thechfrmitotic checkpoint gene in human lung cancer”,Cancer Res.Nov. 1, 2003 63(21): 7185-7189.
Mochan et al., “53BP1, an activator of ATM in resopnse to DNA damage”,DNA Repair(Amst). Aug.-Sep. 2004 3(8-9):945-952.
Mochan et al., “53BP1 and NFBDI/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage”,Cancer Res.Dec. 15, 2003 63(24): 8586-8591.
Stavridi et al., “p53 and stress in the ER”,Genes Dev.Feb. 1, 2004 18(3):241-244.
Venere et al., “Chk2 leaves the PML depot”,Nature Cell Biol.Nov. 2002 4(11):E255-E256.
Cortez et al., “Cell cycle: Conducting the mitotic symphony”NatureJul. 27, 2000 406(6794):430-435.
NCBI Database Accession No. AA223491 “cDNA clone IMAGE:650972”, 1996.
NCBI Database Accession No. AA223601 “cDNA clone IMAGE:650972”, 1996.
NCBI Database Accession No. AA569875 “cDNA clone IMAGE:1071323”, 1997.
Halazonetis Thanos
Scolnick Daniel
Davis Minh-Tam
Howson and Howson
Siew Jeffrey
The Wistar Institute of Anatomy and Biology
LandOfFree
Compositions and methods to enhance sensitivity of cancer... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods to enhance sensitivity of cancer..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods to enhance sensitivity of cancer... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3876911