Compositions and methods to control bleeding

Details Compositions and methods to control bleeding Compositions and methods to control bleeding

2006-03-21

2006-03-21

Steadman, David J. (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S802000, C514S834000, C530S380000, C530S381000, C530S383000, C530S384000

Reexamination Certificate

active

07015193

ABSTRACT:
Disclosed are compositions for treating blood coagulation disorders and allows for manipulation of the blood coagulation cascade. More particularly the invention, relates to compositions for altering bleeding that include a mixture of at least one blood coagulation factor in a low dose and phospholipid vesicles. The invention has a variety of important uses including controlling bleeding in a mammal that has or is suspected of having a potentially life-threatening blood coagulation disorder.

REFERENCES:
patent: 6248353 (2001-06-01), Singh
Fatouros et al. Recombinant Factor VIII SQ—Stability of VIII:C in Homogenates from Porcine, Monkey, Human Subcutaneous Tissue (Jul. 2000) J. Pharm. Pharmacol. vol. 52, pp. 797-805.
Lawson et al. Cooperative Activation of Human Factor IX by the Human Extrinsic Pathway of Blood Coagulation (1991) J. Biol. Chem. vol. 266, No. 17, pp. 11317-1327.
Monroe et al. Mechanism of Action of High-Dose Factor VIIa, Points of Agreement and Disagreement (2003) Arterioscler. Thromb. Vasc. Biol. vol. 23, pp. 8-9.
Butenas et al. Influence of Factor VIIa and Phospholipids on Coagulation in “Acquired” Hemophilia (2003) vol. 23, pp. 123-129.
Lawson et al. The Activation of Factor IX by the Tissue Factor/Factor VIIa and Factor Xa/PCPS Enzyme Complexes in a Completely Human System. (1990) Circulation, vol. 82, No. 4, Suppl. III, pp. 304, abstract 1207.
S. Raut et al.,Brit. J. Haem., 107:323-329 (1999).
P. Lollar et al.,Blood, 63(6):1303-1308 (1984).
A. R. Giles et al.,Blood, 59(2):401-407 (1982).
J. M. Beals et al.,Biochem, J. 235:861-869 (1986).
D. L. Higgins et al.,The Journal of Biological Chemistry; 258(10):6503-6508 (1983).

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