Compositions and methods therewith for penicillin hypersensitivi

Details Compositions and methods therewith for penicillin hypersensitivi Compositions and methods therewith for penicillin hypersensitivi

1975-01-10

1976-09-07

Thomas, Jr., James O.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 12, 424 78, 424 85, 424 88, 424177, A61K 2900, A61K 3143, A61K 3702

Patent

active

039795080

ABSTRACT:
The stereo-isomeric penicilloyl-polylysine conjugates having high optical dextro-rotations are useful for eliciting cutaneous responses in persons with penicillin hypersensitivity.
The process for manufacturing the above-entitled stereo-specific conjugates reacts penicillin with neutralized polylysine hydrochloride in a non-aqueous polar solvent such as dimethyl sulfoxide.

REFERENCES:
parker, J. Lab. & Clin. Med, vol. 62, 1963 p. 482.
Levine, J. of Med. Chem., vol. 7, 1964, p. 675.
Fellner, J. of Allergy, vol. 36, 1965, p. 342.

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