Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2002-02-28
2008-10-07
Switzer, Juliet C (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200
Reexamination Certificate
active
07432049
ABSTRACT:
The invention provides for nucleic acid sequences that are expressed in chondrocytes from any of the following developmental and disease stages: fetal, normal, mild osteoarthritic, moderate osteoarthritic, marked and osteoarthritic. The invention also relates to arrays and compositions comprising any combination of these nucleic acid sequences. The invention also provides for methods of using the arrays of the invention to diagnose osteoarthritis. The invention also provides for methods of identifying therapeutic agents that alter the level of expression of the nucleic acids of the invention or alter the anabolic level of a chondrocyte.
REFERENCES:
patent: 5539096 (1996-07-01), Babai et al.
patent: 0 705 842 (1996-04-01), None
patent: 0705842 (1996-04-01), None
patent: WO 99 32610 (1999-07-01), None
Todesco et al., Journal of Rheumatology, 1980, 7(4)555-558.
Reimer et al. Journal of Virology, 2000, vol. 74, No. 21, pp. 10245-10248.
Kumar et al., (2001), “Identification and Initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries,”Osteoarthritis and cartilage/OARSV.9(7) p. 641-653.
Database EMBL Online! Van Asseldonk et al.,Homo Sapiens Alpha Gene Sequence, Database accession No. AF203815, XP002243659, Abstract, Jun. 6, 2003.
Andrews J. et al.,Gene Discovery Using Computational and Microarray Analysis of Transcription in the Drosophila Melanogaster Testis.Genome Research, vol. 10, Dec. 2000, pp. 2030-2043.
Patel I.R. et al.,TNF-Alpha Convertase Enzyme From Human Arthritis—Affected Cartilage: Isolation of cDNA by Differential Display, Expression of the Active enzyme, and Regulation of TNF—Alpha, The Journal of Immunology, 1998, 160: pp. 4570-4579.
Shukunami et al.,Expression of Cartilage-Specific Functional Matrix Chondromodulin-I mRNA in Rabbit Growth Plate Chondrocytes and Its Responsiveness to Growth Stimuli in Vitro, Biochemical and Biophysical Research Communication, vol. 249, No. 3, Aug. 28, 1998, pp. 885-890.
Alizadeh A. et al.,The Lymphochip: A Specialized CDNA Microarray for the Genomic-Scale Analysis of Gene Expression in Normal and Malignant Lymphocytes, Cold Spring Harbor Symposia on Quantitative Biology, vol. 64, No. 1, 1999, pp. 71-78.
Duggan D. J. et al,Expression Profiling Using cDNA Microarrays, Nature Genetics, vol. 21, , Jan. 1999, pp. 10-14.
Aigner T, Zien A, Gehrsitz A, Gebhard PM, McKenna L. Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology. Arthritis Rheum. Dec. 2001;44(12):2777-89.
European Search Report for Application No. EP 03 75 4646, Dec. 6, 2007.
Bayliss M. T. et al.(Jan. 2001) Osteoarthritis and Cartilage, vol. 9: (1):42-48.
Nentwich et al. (May 3, 2002) J. Biol. Chem. 277(18):15354-15362.
Liew Choong-Chin
Marshall Wayne
Zhang Hongwei
Chondrogene Limited
Edwards Angell Palmer & & Dodge LLP
Switzer Juliet C
Williams Kathleen
LandOfFree
Compositions and methods relating to osteoarthritis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods relating to osteoarthritis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods relating to osteoarthritis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3997090