Compositions and methods relating to novel benzodiazepine...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S221000

Reexamination Certificate

active

07638624

ABSTRACT:
The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.

REFERENCES:
patent: 2457405 (1948-12-01), Scott
patent: 3261828 (1966-07-01), Uskokovic
patent: 3384635 (1968-05-01), Calabateas
patent: 3415814 (1968-12-01), Calabeteas
patent: 3847905 (1974-11-01), Bub
patent: 4076823 (1978-02-01), Wade
patent: 4088756 (1978-05-01), Voorhees
patent: 4108852 (1978-08-01), Bub
patent: 4110337 (1978-08-01), Szarvasi
patent: RE30293 (1980-06-01), Bub
patent: 4495101 (1985-01-01), Klaubert
patent: 4551480 (1985-11-01), Stiefel
patent: 4751223 (1988-06-01), Glamkowski
patent: 4820834 (1989-04-01), Evans
patent: 4894366 (1990-01-01), Okuhara
patent: 4898861 (1990-02-01), Morgan
patent: 4916138 (1990-04-01), Ueda
patent: 4929611 (1990-05-01), Okuhara
patent: 4946778 (1990-08-01), Ladner
patent: 5041438 (1991-08-01), Hsu
patent: 5141930 (1992-08-01), Nakao
patent: 5216148 (1993-06-01), Klaus
patent: 5288514 (1994-02-01), Ellman
patent: 5324726 (1994-06-01), Bock
patent: 5444092 (1995-08-01), Collins
patent: 5521170 (1996-05-01), Setoi et al.
patent: 5545568 (1996-08-01), Ellman
patent: 5559230 (1996-09-01), Ogawa
patent: 5591227 (1997-01-01), Dihn
patent: 5597915 (1997-01-01), Chambers
patent: 5599352 (1997-02-01), Dihn
patent: 5633251 (1997-05-01), Claremon
patent: 5677282 (1997-10-01), Oleksyszyn et al.
patent: 5697967 (1997-12-01), Dihn
patent: 5763437 (1998-06-01), Sato
patent: 5776946 (1998-07-01), McGeer
patent: 5861380 (1999-01-01), Gyorkos
patent: 5962337 (1999-10-01), Ohlmeyer
patent: 6004942 (1999-12-01), Firestein
patent: 6074859 (2000-06-01), Hirokawa
patent: 6080568 (2000-06-01), Glick
patent: 6100254 (2000-08-01), Budde
patent: 6239131 (2001-05-01), Shinozaki et al.
patent: 6277844 (2001-08-01), Spector
patent: 6319931 (2001-11-01), Kroemer
patent: 6506744 (2003-01-01), Alig
patent: 6524623 (2003-02-01), Hodosh
patent: 6524832 (2003-02-01), Kufe
patent: 6579854 (2003-06-01), Mitchell
patent: 6605593 (2003-08-01), Naicker
patent: 6613739 (2003-09-01), Naicker
patent: 6767533 (2004-07-01), Casellas
patent: 6824561 (2004-11-01), Soykan
patent: 6916813 (2005-07-01), Atwal
patent: 7125866 (2006-10-01), Glick
patent: 7144880 (2006-12-01), Glick
patent: 7175953 (2007-02-01), Licha et al.
patent: 7220739 (2007-05-01), Glick
patent: 7276348 (2007-10-01), Glick
patent: 2002/0025946 (2002-02-01), Buchanan
patent: 2002/0048566 (2002-04-01), El-Deiry
patent: 2002/0128208 (2002-09-01), Snyder
patent: 2003/0044776 (2003-03-01), Dykens
patent: 2003/0119029 (2003-06-01), Glick
patent: 2004/0009972 (2004-01-01), Ding
patent: 2004/0087489 (2004-05-01), Ruiz
patent: 2004/0157833 (2004-08-01), Harris
patent: 2004/0176358 (2004-09-01), Glick
patent: 2005/0113460 (2005-05-01), Glick
patent: 2005/0261176 (2005-11-01), Glick
patent: 2005/0272723 (2005-12-01), Glick
patent: 2006/0025388 (2006-02-01), Glick
patent: 2006/0052369 (2006-03-01), Glick
patent: 2006/0166975 (2006-07-01), Glick
patent: 2007/0036854 (2007-02-01), Glick
patent: 2007/0043033 (2007-02-01), Glick
patent: 2007/0105844 (2007-05-01), Glick
patent: 2007/0111994 (2007-05-01), Glick
patent: 2007/0135418 (2007-06-01), Glick
patent: 2007/0299059 (2007-12-01), Glick
patent: 2008/0064686 (2008-03-01), Durrani
patent: 1810423 (1969-10-01), None
patent: 0349949 (1990-01-01), None
patent: 0227539 (1990-05-01), None
patent: 0349949 (1990-10-01), None
patent: 1143946 (2001-10-01), None
patent: 1423122 (2003-02-01), None
patent: 1398033 (2004-03-01), None
patent: 1398033 (2004-06-01), None
patent: 1622684 (2006-02-01), None
patent: 1742640 (2006-07-01), None
patent: 1778204 (2007-05-01), None
patent: 1786429 (2007-05-01), None
patent: 1845996 (2007-10-01), None
patent: 2096044 (1997-11-01), None
patent: 90/05305 (1990-05-01), None
patent: 90/13332 (1990-11-01), None
patent: 91/12779 (1991-09-01), None
patent: 92/01683 (1992-02-01), None
patent: 94/08234 (1994-04-01), None
patent: 98/57161 (1998-12-01), None
patent: 99/29347 (1999-06-01), None
patent: 99/58117 (1999-11-01), None
patent: 99/66958 (1999-12-01), None
patent: 99/67220 (1999-12-01), None
patent: 00/19200 (2000-06-01), None
patent: 00/66106 (2000-11-01), None
patent: 01/51922 (2001-07-01), None
patent: 02/67988 (2002-09-01), None
patent: 03/015703 (2003-02-01), None
patent: 03/041658 (2003-05-01), None
patent: 03/050261 (2003-06-01), None
patent: 03/106628 (2003-12-01), None
patent: 2005/004988 (2005-01-01), None
patent: 2006/014526 (2006-02-01), None
patent: 2006/029245 (2006-03-01), None
patent: 2006/073448 (2006-07-01), None
patent: 2006/074358 (2006-07-01), None
patent: 2007/050587 (2007-05-01), None
patent: 2007/053193 (2007-05-01), None
patent: 2007/053725 (2007-05-01), None
patent: 2007/146167 (2007-12-01), None
patent: 2008/012553 (2008-09-01), None
patent: 2008/116156 (2008-09-01), None
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
Puodziunaite et al. Chemistry of Heterocyclic Compounds, vol. 36, No. 6, 2000, pp. 698-704.
Lee et al. J. Org. Chem. 1999, 64, 3060-3065.
Solomko et al. Chemistry of Heterocyclic Compounds, vol. 11, No. 11, Nov. 1975, pp. 1231-1248.
Thompson, C.B., “Apoptosis in the Pathogenesis and Treatment of Disease,” Science 267:1456-1462 (1995).
Ursini et al., “Synthesis and SAR of New 5-Phenyl-3-ureido-1,5-benzodiazepines as cholecystokinin-B receptor antagonists”, J. Med. Chem. 43 (2000) 3596-3613.
Walser, et al., “Quinazolines and 1,4-benzodiazepines. LILX. Preparation of Pyrrolo[2,1-c]-1,4-benzodiazepin-2-ones”, J. Org. Chem. 38:3502-3507 (1973).
Watanabe-Fukunaga, R., et al., “Lymphoproliferation Disorder in Mice Explained by Defects in Fas Antigen that Mediates Apoptosia,”Nature 356:314-317 (1992).
White, E., “Life, Death, and the Pursuit of Apoptosis,” Genes & Development 10:1-15 (1996).
Williams, D. et al, “Identification of compounds the bind mitochondrial F1F0 ATPase by screening a triazine library . . . ” Chemistry & Biol. 11:1251-1259, 9(2004).
Wu, G.Y., et al., “Receptor-Mediated in Vitro Gene Transformation by a Soluble DNA Carrier System,” The Journal of Biological Chemistry 262(10):4429-4432 (1987).
Wyllie, A.H., “The Genetic Regulation of Apoptosis,” Current Opinion in Genetics & Development 5:97-104 (1995).
Zamzami, N., et al., “Mitochondrial Control of Nuclear Apoptosis,” J. Exp. Med. 183:1533-1544 1996.
Zoratti, M., et al., “The Mitochondrial Permeability Transition,” Biochimica et Biophysica Acta 1241:139-176 (1995).
International Search Report, International Patent Application No. PCT/U505/24060, dated Dec. 13, 2006.
International Search Report, International Patent Application No. PCT/US02/26171 dated Aug. 8, 2003.
International Search Report, International Patent Application No. PCT/US01/11599 dated Mar. 6, 2001.
International Search Report, International Patent Application No. PCT/US005/031942 dated Sep. 21, 2006.
International Search Report, International Patent Application No. PCT/US04/013455 dated Jan. 6, 2006.
European Search Report, EP Patent Application No. 03 027 484.9-2117 dated May 3, 2004.
European Search Report, EP Patent Application No. 04 775 923.8-2123 dated Nov. 9, 2007.
European Search Report, EP Patent Application No. 00 928 586.7-2117 dated Apr. 23, 2002.
European Search Report, EP Patent Application No. 05 769 345.9 dated Oct. 22, 2007.
International Search Report, PCT/US2006/042753, dated May 6, 2008.
Witten Opinion of the International Searching Authority, PCT/US06/21561, dated Aug. 17, 2007.
International Preliminary Report on Patentability, PCT/US2006/041446, mailed May 8, 2008.
International Search Repor

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