Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-04-03
2000-05-09
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 232, C12Q 170
Patent
active
060602414
ABSTRACT:
A poly-3-hydroxybutyrate metabolic pathway essential for Helicobacter pylori survival in a host is provided. A novel Helicobacter pylori Coenzyme A transferase (Hp CoA-t), thiolase and PHB synthase as well as methods for their preparation and use are provided. Hp CoA-t and thiolase polynucleotides and proteins are provided as well as detection and preparative methods using such molecules. Methods for the determination of a propensity to develop gastritis, peptic ulcer disease, or gastric cancer is provided for by detection methods. Methods are also provided for the use of Hp CoA-t, thiolase or PHB synthase proteins and fragments retaining enzymatic activity in the identification of potential drug candidates for the treatment of some types of gastric disease. Pharmaceutical compositions containing Hp CoA-t protein fragments, antisense nucleic acids or other inhibitors of Hp CoA-t, thiolase and PHB synthase as well as methods for their use in the treatment of some types of gastric disease are also provided.
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Housel James C.
Kieta Holding SA
Portner Ginny Allen
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